5-HT2A receptor

HTR2A
Identifiers
Aliases	HTR2A, 5-HT2A, HTR2, 5-hydroxytryptamine receptor 2A
External IDs	OMIM: 182135 MGI: 109521 HomoloGene: 68073 GeneCards: HTR2A
Targeted by Drug
LP-12, LP-44, 5-carboxamidotryptamine, pathogen, 5-methoxytryptamine, (+/-)-8-hydroxy-2-(di-N-propylamino)tetralin, AL-37350A, α-methyl-5-HT, aripiprazole, brl-15572, brolamfetamine, BW723C86, cabergoline, cgs 12066b-parent, 4-iodo-2,5-dimethoxyphenylisopropylamine, donitriptan, gr-127935, lorcaserin, lysergide, methylergonovine, mk-212, Org 12962, ORG-37684, pergolide, pindolol, quetiapine, quinpirole, quipazine, ru-24969, sb-216641, 1-(3-trifluoromethylphenyl)piperazine, tryptamine, VER-3323, bromocriptine, ergotamine, m-chlorophenylpiperazine, lisuride, terguride, agomelatine, apomorphine, blonanserin, bufotenine, (+)-butaclamol, cyamemazine, duloxetine, flibanserin, fluphenazine, fluspirilene, glemanserin, haloperidol, ketanserin, L-741,626, LY215840, mesoridazine, mesulergine, metergoline, metitepine, methysergide, mianserin, mirtazapine, molindone, nefazodone, olanzapine, perphenazine, pimozide, pipamperone, ritanserin, roxindole, RS-102221, rs-127445, sarpogrelate, sb-206553, SB 242084, SB 243213, SDZ SER-082, sertindole, spiperone, spiramide, thioridazine, thiothixene, trazodone, trifluoperazine, volinanserin, vortioxetine, xanomeline, ziprasidone, zotepine, chlorpromazine, clozapine, loxapine, pimavanserin, risperidone
Gene ontology Molecular function • 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding • G-protein coupled receptor activity • virus receptor activity • protein complex binding • signal transducer activity • drug binding • G-protein alpha-subunit binding • G-protein coupled serotonin receptor activity • serotonin binding • neurotransmitter receptor activity Cellular component • cytoplasm • integral component of membrane • cytosol • cell projection • membrane • cell body fiber • integral component of plasma membrane • dendritic shaft • axon • neuronal cell body • caveola • cytoplasmic vesicle • plasma membrane • dendrite Biological process • detection of mechanical stimulus involved in sensory perception of pain • smooth muscle contraction • release of sequestered calcium ion into cytosol • regulation of dopamine secretion • G-protein coupled receptor signaling pathway • regulation of behavior • phospholipase C-activating serotonin receptor signaling pathway • urinary bladder smooth muscle contraction • positive regulation of MAP kinase activity • behavior • behavioral response to cocaine • positive regulation of cytosolic calcium ion concentration • positive regulation of kinase activity • positive regulation of phosphatidylinositol biosynthetic process • aging • cellular calcium ion homeostasis • cell death • memory • activation of phospholipase C activity • detection of temperature stimulus involved in sensory perception of pain • protein localization to cytoskeleton • sleep • positive regulation of vasoconstriction • positive regulation of cell proliferation • negative regulation of potassium ion transport • positive regulation of ERK1 and ERK2 cascade • artery smooth muscle contraction • positive regulation of peptidyl-tyrosine phosphorylation • viral entry into host cell • phosphatidylinositol 3-kinase signaling • sensory perception of pain • regulation of hormone secretion • temperature homeostasis • viral process • positive regulation of fat cell differentiation • positive regulation of glycolytic process • negative regulation of synaptic transmission, glutamatergic • signal transduction • chemical synaptic transmission • response to drug • serotonin receptor signaling pathway • phospholipase C-activating G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3356	15558
Ensembl	ENSG00000102468	ENSMUSG00000034997
UniProt	P28223	P35363
RefSeq (mRNA)	NM_001165947 NM_000621	NM_172812
RefSeq (protein)	NP_000612 NP_001159419	NP_766400.1 NP_766400
Location (UCSC)	Chr 13: 46.83 – 46.9 Mb	Chr 14: 74.64 – 74.71 Mb
PubMed search

3356

15558

ENSG00000102468

ENSMUSG00000034997

P28223

P35363

NM_001165947
NM_000621

NM_172812

NP_000612
NP_001159419

NP_766400.1
NP_766400

The mammalian 5-HT_2A receptor is a subtype of the 5-HT₂ receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR). This is the main excitatory receptor subtype among the GPCRs for serotonin (5-HT), although 5-HT_2A may also have an inhibitory effect on certain areas such as the visual cortex and the orbitofrontal cortex. This receptor was first noted for its importance as a target of serotonergic psychedelic drugs such as LSD. Later it came back to prominence because it was also found to be mediating, at least partly, the action of many antipsychotic drugs, especially the atypical ones.

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