Quinpirole

Quinpirole
Names

IUPAC name (4aR,8aR)-5-propyl-4,4a,5,6,7,8,8a,9-octahydro-1H-pyrazolo[3,4-g]quinoline
Identifiers
CAS Number	80373-22-4^Y
3D model (Jmol)	Interactive image
ChEBI	CHEBI:75401^N
ChemSpider	49279^N
IUPHAR/BPS	2
MeSH	D019257
PubChem CID	54562
UNII	20OP60125T^N
InChI InChI=1S/C13H21N3/c1-2-5-16-6-3-4-10-7-12-11(8-13(10)16)9-14-15-12/h9-10,13H,2-8H2,1H3,(H,14,15)/t10-,13-/m1/s1^N Key: FTSUPYGMFAPCFZ-ZWNOBZJWSA-N^N InChI=1/C13H21N3/c1-2-5-16-6-3-4-10-7-12-11(8-13(10)16)9-14-15-12/h9-10,13H,2-8H2,1H3,(H,14,15)/t10-,13-/m1/s1 Key: FTSUPYGMFAPCFZ-ZWNOBZJWBQ
SMILES CCCN1CCC[C@H]2[C@H]1CC3=C(C2)NN=C3
Properties
Chemical formula	C₁₃H₂₁N₃
Molar mass	219.33 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N (what is ^YN ?)
Infobox references

Quinpirole is a psychoactive drug and research chemical which acts as a selective D₂ and D₃ receptor agonist. It is used in scientific research. Quinpirole has been shown to increase locomotion and sniffing behavior in mice treated with it. At least one study has found that quinpirole induces compulsive behavior symptomatic of obsessive compulsive disorder in rats. Another study in rats show that quinpirole produces significant THC-like effects when metabolic degradation of anandamide is inhibited, supporting the hypothesis that these effects of quinpirole are mediated by cannabinoid CB₁ receptors.

Experiments in flies found quinpirole may have neuroprotective effects against Parkinson's disease-like pathology. Moreover, in primary neuronal cultures it also reduces the rate of firing in dopaminergic neurons.

...
Wikipedia