Cannabinoid receptor type 1

CNR1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1LVQ, 1LVR, 2B0Y, 2KOE, 2MZ3, 2MZ2, 2MZA,%%s1LVQ, 1LVR, 2B0Y, 2KOE

Identifiers

Aliases

CNR1, CANN6, CB-R, CB1, CB1A, CB1K5, CB1R, CNR, cannabinoid receptor 1 (brain)

External IDs

MGI: 104615 HomoloGene: 7273 GeneCards: CNR1

Targeted by Drug

hu-210, win 55212-2, anandamide, cannabinol, dronabinol, Org27569, ly-320135, rimonabant, TM-38837

Gene ontology
Molecular function	• G-protein coupled receptor activity • signal transducer activity • cannabinoid receptor activity • drug binding
Cellular component	• integral component of membrane • intracellular membrane-bounded organelle • membrane • growth cone • integral component of plasma membrane • axon • membrane raft • plasma membrane • actin cytoskeleton • presynaptic membrane
Biological process	• G-protein coupled receptor signaling pathway • negative regulation of nitric-oxide synthase activity • negative regulation of mast cell activation • glucose homeostasis • response to nutrient • regulation of insulin secretion • negative regulation of blood pressure • adenylate cyclase-modulating G-protein coupled receptor signaling pathway • cannabinoid signaling pathway • maternal process involved in female pregnancy • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • response to nicotine • aging • positive regulation of fever generation • memory • negative regulation of action potential • regulation of feeding behavior • negative regulation of ion transport • response to morphine • negative regulation of fatty acid beta-oxidation • response to lipopolysaccharide • positive regulation of blood pressure • regulation of penile erection • regulation of lipid metabolic process • spermatogenesis • positive regulation of neuron projection development • positive regulation of apoptotic process • positive regulation of acute inflammatory response to antigenic stimulus • learning or memory • sensory perception of pain • negative regulation of dopamine secretion • regulation of synaptic transmission, glutamatergic • response to ethanol • axonal fasciculation • regulation of synaptic transmission, GABAergic • signal transduction • response to cocaine • trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


1268


12801

Ensembl


ENSG00000118432


ENSMUSG00000044288

UniProt


P21554


P47746

RefSeq (mRNA)

NM_001160226 NM_001160258 NM_001160259 NM_001160260 NM_016083
NM_033181


NM_007726

RefSeq (protein)


NP_001153698 NP_001153730 NP_001153731 NP_057167 NP_149421


NP_031752.1 NP_031752

Location (UCSC)

Chr 6: 88.14 – 88.17 Mb

Chr 4: 33.92 – 33.95 Mb

PubMed search

1LVQ, 1LVR, 2B0Y, 2KOE, 2MZ3, 2MZ2, 2MZA,%%s1LVQ, 1LVR, 2B0Y, 2KOE

NP_001153698
NP_001153730
NP_001153731
NP_057167
NP_149421

...
Wikipedia