D3 receptor

DRD3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3PBL
Identifiers
Aliases	DRD3, D3DR, ETM1, FET1, dopamine receptor D3
External IDs	MGI: 94925 HomoloGene: 623 GeneCards: DRD3
Targeted by Drug
PF-592379, ropinirole, rotigotine, vilazodone, 7-hydroxy-2-(di-N-propylamino)tetralin, dopamine, pramipexole, quinelorane, quinpirole, apomorphine, do-687, bromocriptine, cabergoline, lisuride, pergolide, piribedil, roxindole, terguride, (+)-butaclamol, chlorpromazine, clozapine, domperidone, eticlopride, (Z)-flupentixol, haloperidol, loxapine, mesoridazine, nafadotride, nemonapride, perospirone, pimozide, prochlorperazine, promazine, raclopride, risperidone, SB-277,011-A, sertindole, spiperone, sulpiride, levosulpiride, zotepine
Gene ontology Molecular function • protein binding • signal transducer activity • G-protein coupled receptor activity • dopamine neurotransmitter receptor activity • protein domain specific binding • D1 dopamine receptor binding • drug binding • dopamine neurotransmitter receptor activity, coupled via Gi/Go • dopamine binding Cellular component • endocytic vesicle • apical part of cell • cell projection • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane Biological process • negative regulation of sodium:proton antiporter activity • dopamine receptor signaling pathway • dopamine metabolic process • regulation of circadian sleep/wake cycle, sleep • negative regulation of dopamine receptor signaling pathway • positive regulation of cell proliferation • regulation of dopamine uptake involved in synaptic transmission • response to histamine • response to ethanol • prepulse inhibition • social behavior • learning • positive regulation of renal sodium excretion • arachidonic acid secretion • negative regulation of protein secretion • negative regulation of transcription from RNA polymerase II promoter • gastric emptying • regulation of blood volume by renin-angiotensin • regulation of locomotion involved in locomotory behavior • cellular calcium ion homeostasis • regulation of locomotion • learning or memory • response to amphetamine • positive regulation of transcription from RNA polymerase II promoter • positive regulation of cytokinesis • signal transduction • regulation of lipid metabolic process • regulation of multicellular organism growth • visual learning • G-protein coupled receptor internalization • G-protein coupled receptor signaling pathway • regulation of dopamine secretion • negative regulation of adenylate cyclase activity • negative regulation of protein kinase B signaling • adenylate cyclase-activating dopamine receptor signaling pathway • locomotory behavior • behavioral response to cocaine • negative regulation of blood pressure • acid secretion • musculoskeletal movement, spinal reflex action • positive regulation of dopamine receptor signaling pathway • circadian regulation of gene expression • response to morphine • negative regulation of oligodendrocyte differentiation • adenylate cyclase-inhibiting dopamine receptor signaling pathway • regulation of cAMP metabolic process • positive regulation of mitotic nuclear division • response to drug • response to cocaine • synaptic transmission, dopaminergic Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1814	13490
Ensembl	ENSG00000151577	ENSMUSG00000022705
UniProt	P35462	P30728
RefSeq (mRNA)	NM_000796 NM_001282563 NM_001290809 NM_033658 NM_033659 NM_033660 NM_033663	NM_007877
RefSeq (protein)	NP_000787 NP_001269492 NP_001277738 NP_387512	NP_031903.1 NP_031903
Location (UCSC)	Chr 3: 114.13 – 114.2 Mb	Chr 16: 43.76 – 43.82 Mb
PubMed search

3PBL

1814

13490

ENSG00000151577

ENSMUSG00000022705

P35462

P30728

NM_033660
NM_033663

NM_007877

NP_000787
NP_001269492
NP_001277738
NP_387512

NP_031903.1
NP_031903

Dopamine receptor D₃ is a protein that in humans is encoded by the DRD3 gene.

This gene encodes the D₃ subtype of the dopamine receptor. The D₃ subtype inhibits adenylyl cyclase through inhibitory G-proteins. This receptor is expressed in phylogenetically older regions of the brain, suggesting that this receptor plays a role in cognitive and emotional functions. It is a target for drugs which treat schizophrenia, drug addiction, and Parkinson's disease. Alternative splicing of this gene results in multiple transcript variants that would encode different isoforms, although some variants may be subject to nonsense-mediated decay (NMD).

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