Domperidone

Domperidone
Clinical data


Trade names	Motilium, many others
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy category	US: Not classified
Routes of administration	Oral, intramuscular, intravenous (d/c'd), rectal
ATC code	A03FA03 (WHO) QP51AX24 (WHO)
Legal status
Legal status	UK: POM (Prescription only) US: Not approved for use or sale prescription medicine (Rx only): India, Australia, Canada, Israel, Belgium; over-the-counter: Egypt, Ireland, Italy, Japan, Netherlands, South Africa, Switzerland, China, Russia, Slovakia, Ukraine Thailand, Malta, South Korea, and Romania
Pharmacokinetic data
Bioavailability	Oral: 13–17% Intramuscular: 90%
Protein binding	~92%
Metabolism	Hepatic (CYP3A4/5) and intestinal (first-pass)
Metabolites	All inactive
Biological half-life	7.5 hours
Excretion	Feces: 66% Urine: 32% Breast milk: small quantities
Identifiers
IUPAC name 5-Chloro-1-(1-[3-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propyl]piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
CAS Number	57808-66-9^Y
PubChem CID	3151
IUPHAR/BPS	965
DrugBank	DB01184^Y
ChemSpider	3039^Y
UNII	5587267Z69
KEGG	D01745^Y
ChEBI	CHEBI:31515^Y
ChEMBL	CHEMBL219916^Y
ECHA InfoCard	100.055.408
Chemical and physical data
Formula	C₂₂H₂₄ClN₅O₂
Molar mass	425.911 g/mol
3D model (Jmol)	Interactive image
Melting point	242.5 °C (468.5 °F)
SMILES Clc1cc2c(cc1)N(C(=O)N2)C5CCN(CCCN4c3ccccc3NC4=O)CC5
InChI InChI=1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30)^Y Key:FGXWKSZFVQUSTL-UHFFFAOYSA-N^Y

Domperidone, sold under the brand name Motilium among others, is a peripherally selective dopamine D₂ receptor antagonist that was developed by Janssen Pharmaceutica and is used as an antiemetic, gastroprokinetic agent, and galactagogue. It may be administered orally or rectally, and is available in the form of tablets, orally disintegrating tablets (based on Zydis technology),suspension, and suppositories. The drug is used to relieve nausea and vomiting; to increase the transit of food through the stomach (by increasing gastrointestinal peristalsis); and to promote lactation (breast milk production) by release of prolactin.

The uses or indications of domperidone vary between nations. For instance, in Italy it is used in the treatment of gastroesophageal reflux disease and in Canada, the drug is indicated in upper gastrointestinal motility disorders and to prevent gastrointestinal symptoms associated with the use of dopamine agonist antiparkinsonian agents. In the United States, domperidone is not currently a legally marketed human drug and it is not approved for sale in the U.S. On 7 June 2004, FDA issued a public warning that distributing any domperidone-containing products is illegal. In the United Kingdom, domperidone is only indicated for the treatment of nausea and vomiting and the treatment duration is usually limited to 1 week.

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Wikipedia