CYP3A4

CYP3A4
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1TQN, 1W0E, 1W0F, 1W0G, 2J0D, 2V0M, 3NXU, 3TJS, 3UA1, 4I3Q, 4I4G, 4I4H, 4K9T, 4K9U, 4K9V, 4K9W, 4K9X, 4NY4, 5A1P, 5A1R, 4D6Z, 4D75, 4D78, 4D7D
Identifiers
Aliases	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1, cytochrome P450 family 3 subfamily A member 4
External IDs	OMIM: 124010 HomoloGene: 111391 GeneCards: CYP3A4
EC number	1.14.13.32
Targeted by Drug
nefazodone, ritonavir, verapamil
Gene ontology Molecular function • metal ion binding • albendazole monooxygenase activity • aromatase activity • heme binding • caffeine oxidase activity • testosterone 6-beta-hydroxylase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • quinine 3-monooxygenase activity • taurochenodeoxycholate 6alpha-hydroxylase activity • steroid binding • vitamin D3 25-hydroxylase activity • steroid hydroxylase activity • vitamin D 24-hydroxylase activity • oxygen binding • enzyme binding • iron ion binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen • monooxygenase activity • oxidoreductase activity • estrogen 16-alpha-hydroxylase activity • 1,8-cineole 2-exo-monooxygenase activity Cellular component • cytoplasm • integral component of membrane • membrane • endoplasmic reticulum • organelle membrane • endoplasmic reticulum membrane • intracellular membrane-bounded organelle Biological process • drug metabolic process • xenobiotic metabolic process • heterocycle metabolic process • drug catabolic process • oxidative demethylation • monoterpenoid metabolic process • exogenous drug catabolic process • steroid catabolic process • androgen metabolic process • alkaloid catabolic process • vitamin D metabolic process • lipid metabolic process • oxidation-reduction process • calcitriol biosynthetic process from calciol • lipid hydroxylation • steroid metabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1576	n/a
Ensembl	ENSG00000160868	n/a
UniProt	P08684	n/a
RefSeq (mRNA)	NM_001202855 NM_001202856 NM_001202857 NM_017460	n/a
RefSeq (protein)	NP_001189784 NP_059488	n/a
Location (UCSC)	Chr 7: 99.76 – 99.78 Mb	n/a
PubMed search		n/a

1TQN, 1W0E, 1W0F, 1W0G, 2J0D, 2V0M, 3NXU, 3TJS, 3UA1, 4I3Q, 4I4G, 4I4H, 4K9T, 4K9U, 4K9V, 4K9W, 4K9X, 4NY4, 5A1P, 5A1R, 4D6Z, 4D75, 4D78, 4D7D

1576

n/a

ENSG00000160868

...
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