*** Welcome to piglix ***

Rotigotine

Rotigotine
Rotigotin Enantiomer Structural Formulae.png
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
MedlinePlus a607059
Pregnancy
category
  • C
Routes of
administration
Transdermal patch
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability 37% (transdermal)
Protein binding 92%
Metabolism Hepatic (-mediated)
Biological half-life 5–7 hours
Excretion Urine (71%), Fecal (23%)
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
ChEMBL
Chemical and physical data
Formula C19H25NOS
Molar mass 315.474 g/mol
3D model (Jmol)
 NYesY (what is this?)  

Rotigotine (Neupro) is a dopamine agonist of the non-ergoline class of medications indicated for the treatment of Parkinson's disease (PD) and restless legs syndrome (RLS). It is formulated as a once-daily transdermal patch which provides a slow and constant supply of the drug over the course of 24 hours.

Like other dopamine agonists, rotigotine has been shown to possess antidepressant effects and may be useful in the treatment of depression as well.

Rotigotine was first developed in 1985 as N-0427 by a team from the University of Groningen. Development was then continued by Aderis Pharmaceuticals. In 1998, Aderis licensed worldwide development and commercialization rights for rotigotine to the German pharmaceutical company Schwarz Pharma (today a subsidiary of the Belgian company UCB S.A.).

The drug has been approved by the EMEA for use in Europe in 2006 and is today being sold in several European countries. In 2007, the Neupro patch was approved by the Food and Drug Administration (FDA) as the first transdermal treatment of Parkinson's disease in the United States. However, as of 2008, Schwarz Pharma has recalled all Neupro patches in the United States and some in Europe because of problems with the delivery mechanism. The patch was reformulated, and was reintroduced in the United States in 2012.

Rotigotine has been authorized as a treatment for restless legs syndrome since August 2008.

General side effects for rotigotine may include constipation, dyskinesia, nausea, vomiting, dizziness, fatigue, insomnia, somnolence, confusion, and hallucinations. More serious complications can include psychosis and impulse control disorders like hypersexuality, punding, and pathological gambling. Mild adverse skin reactions at the patch application site may also occur.


...
Wikipedia

...