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8-OH-DPAT

8-OH-DPAT
Kekulé, skeletal formula of 8-OH-DPAT
Names
Systematic IUPAC name
7-(Dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol
Identifiers
78950-78-4 N
3D model (Jmol) Interactive image
Interactive image
Abbreviations 8-OH-DPAT
ChEBI CHEBI:73364 N
ChEMBL ChEMBL56 YesY
ChemSpider 1183 YesY
5036174 (R) YesY
8301316 (S) YesY
7
MeSH 8-Hydroxy-2-(di-n-propylamino)tetralin
PubChem 1220
6603866 (R)
10125797 (S)
Properties
C16H25NO
Molar mass 247.38 g·mol−1
log P 3.711
Acidity (pKa) 10.539
Basicity (pKb) 3.458
Pharmacology
Pharmacokinetics:
1.5 hours
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N  (what is YesYN ?)
Infobox references

8-OH-DPAT is a research chemical of the aminotetralin chemical class which was developed in the 1980s and has been widely used to study the function of the 5-HT1A receptor. It was one of the first major 5-HT1A receptor full agonists to be discovered.

Originally believed to be selective for the 5-HT1A receptor, 8-OH-DPAT was later found to act as a 5-HT7 receptor agonist and serotonin reuptake inhibitor/releasing agent as well.

In animal studies, 8-OH-DPAT has been shown to possess antidepressant,anxiolytic,serenic,anorectic,antiemetic,hypothermic,hypotensive,bradycardic,hyperventilative, and analgesic effects.



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