Names | |
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Systematic IUPAC name
7-(Dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol
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Identifiers | |
78950-78-4 | |
3D model (Jmol) |
Interactive image Interactive image |
Abbreviations | 8-OH-DPAT |
ChEBI | CHEBI:73364 |
ChEMBL | ChEMBL56 |
ChemSpider |
1183 5036174 (R) 8301316 (S) |
7 | |
MeSH | 8-Hydroxy-2-(di-n-propylamino)tetralin |
PubChem |
1220 6603866 (R) 10125797 (S) |
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Properties | |
C16H25NO | |
Molar mass | 247.38 g·mol−1 |
log P | 3.711 |
Acidity (pKa) | 10.539 |
Basicity (pKb) | 3.458 |
Pharmacology | |
Pharmacokinetics: | |
1.5 hours | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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what is ?) | (|
Infobox references | |
8-OH-DPAT is a research chemical of the aminotetralin chemical class which was developed in the 1980s and has been widely used to study the function of the 5-HT1A receptor. It was one of the first major 5-HT1A receptor full agonists to be discovered.
Originally believed to be selective for the 5-HT1A receptor, 8-OH-DPAT was later found to act as a 5-HT7 receptor agonist and serotonin reuptake inhibitor/releasing agent as well.
In animal studies, 8-OH-DPAT has been shown to possess antidepressant,anxiolytic,serenic,anorectic,antiemetic,hypothermic,hypotensive,bradycardic,hyperventilative, and analgesic effects.