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5-HT7 receptor

HTR7
Identifiers
Aliases HTR7, 5-HT7, 5-HT7 receptor, 5-hydroxytryptamine receptor 7
External IDs MGI: 99841 HomoloGene: 20244 GeneCards: HTR7
Targeted by Drug
AS-19, LP-12, LP-44, 1-naphthylpiperazine, 5-carboxamidotryptamine, pathogen, 5-methoxytryptamine, (+/-)-8-hydroxy-2-(di-N-propylamino)tetralin, EMDT, tryptamine, xanomeline, oleamide, bromolysergide, cyamemazine, cyproheptadine, dihydroergotamine, haloperidol, iloperidone, ketanserin, lurasidone, mesulergine, metergoline, metitepine, methysergide, mianserin, olanzapine, ritanserin, SB269970, spiperone, sumatriptan, vortioxetine, yohimbine, chlorpromazine, clozapine, fluperlapine, fluphenazine, perphenazine, risperidone, SB 258719, thioridazine, ziprasidone, zotepine
RNA expression pattern
PBB GE HTR7 207927 at fs.png

PBB GE HTR7 216098 s at fs.png

PBB GE HTR7 207818 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_019860
NM_000872
NM_019859

NM_008315
NM_001347442

RefSeq (protein)

NP_000863
NP_062873
NP_062874

NP_032341.2
NP_001334371
NP_032341

Location (UCSC) Chr 10: 90.74 – 90.86 Mb Chr 19: 35.96 – 36.06 Mb
PubMed search

NM_019860
NM_000872
NM_019859

NM_008315
NM_001347442

NP_000863
NP_062873
NP_062874

NP_032341.2
NP_001334371
NP_032341

The 5-HT7 receptor is a member of the GPCR superfamily of cell surface receptors and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) The 5-HT7 receptor is coupled to Gs (stimulates the production of the intracellular signaling molecule cAMP) and is expressed in a variety of human tissues, particularly in the brain, the gastrointestinal tract, and in various blood vessels. This receptor has been a drug development target for the treatment of several clinical disorders. The 5-HT7 receptor is encoded by the HTR7 gene, which in humans is transcribed into 3 different splice variants.


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