EMDT

EMDT
Clinical data

ATC code	none
Identifiers
IUPAC name 2-(2-ethyl-5-methoxy-1H-indol-3-yl)-N,N-dimethylethanamine
PubChem CID	6918513
IUPHAR/BPS	12
ChemSpider	5293710^N
Chemical and physical data
Formula	C₁₅H₂₂N₂O
Molar mass	246.347 g/mol
3D model (Jmol)	Interactive image
SMILES CCc2nc1ccc(OC)cc1c2CCN(C)C
InChI InChI=1S/C15H22N2O/c1-5-14-12(8-9-17(2)3)13-10-11(18-4)6-7-15(13)16-14/h6-7,10,16H,5,8-9H2,1-4H3^N Key:ZEYRDXUWJDGTLD-UHFFFAOYSA-N^N
^NY (what is this?)

2-Ethyl-5-methoxy-N,N-dimethyltryptamine (EMDT) is a tryptamine derivative which is used in scientific research. It acts as a selective 5-HT₆ receptor agonist, with a K_i of 16 nM, and was one of the first selective agonists developed for this receptor. EMDT inhibits both short- and long-term memory formation in animal studies, and this effect can be reversed by the selective 5-HT₆ antagonist SB-399,885. Additionally, it is active in the tail suspension test, suggesting that it could be an effective antidepressant.

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