SB-399,885

SB-399885
Identifiers

IUPAC name N-(3,5-Dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)benzenesulfonamide
CAS Number	402713-80-8^Y
PubChem CID	6918649
IUPHAR/BPS	3241
ChemSpider	5293842
ChEMBL	CHEMBL1210710^N
Chemical and physical data
Formula	C₁₈H₂₁Cl₂N₃O₄S
Molar mass	446.347 g/mol
3D model (Jmol)	Interactive image
SMILES C3CNCCN3c2cc(ccc2OC)S(=O)(=O)Nc(c1OC)cc(Cl)cc1Cl
InChI InChI=1S/C18H21Cl2N3O4S/c1-26-17-4-3-13(11-16(17)23-7-5-21-6-8-23)28(24,25)22-15-10-12(19)9-14(20)18(15)27-2/h3-4,9-11,21-22H,5-8H2,1-2H3 Key:ATKZKAYWARYLBW-UHFFFAOYSA-N
^NY (what is this?)

SB-399885 is a drug which is used in scientific research. It acts as a potent, selective and orally active 5-HT₆ receptor antagonist, with a Ki of 9.0nM. SB-399885 and other 5-HT₆ antagonists show nootropic effects in animal studies, as well as antidepressant and anxiolytic effects which are comparable to and synergistic with drugs such as imipramine and diazepam, and have been proposed as potential novel treatments for cognitive disorders such as schizophrenia and Alzheimer's disease.

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