Mianserin

Mianserin
Clinical data


Trade names	Bolvidon (discontinued), Tolvon, Lerivon
AHFS/Drugs.com	International Drug Names
Pregnancy category	AU: B2
Routes of administration	Oral (tablets)
ATC code	N06AX03 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) UK: POM (Prescription only)
Pharmacokinetic data
Bioavailability	20–30%
Protein binding	95%
Metabolism	Hepatic (mediated by CYP2D6; most metabolism occurs via aromatic hydroxylation, N-oxidation and N-demethylation)
Biological half-life	21–61 hours
Excretion	Renal (4–7%) Faecal (14–28%)
Identifiers
IUPAC name (±)-2-methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine
CAS Number	24219-97-4^Y
PubChem CID	4184
IUPHAR/BPS	135
DrugBank	DB06148^N
ChemSpider	4040^Y
UNII	250PJI13LM
KEGG	D08216^Y
ChEBI	CHEBI:51137^N
ChEMBL	CHEMBL6437^Y
ECHA InfoCard	100.041.884
Chemical and physical data
Formula	C₁₈H₂₀N₂
Molar mass	264.365
3D model (Jmol)	Interactive image
SMILES c42c(N3C(c1ccccc1C2)CN(C)CC3)cccc4
InChI InChI=1S/C18H20N2/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19/h2-9,18H,10-13H2,1H3^Y Key:UEQUQVLFIPOEMF-UHFFFAOYSA-N^Y
^NY (what is this?)

Mianserin (brand names: Depnon (IN), Lantanon (ZA), Lerivon (AR, BE, CZ, PL, RU, SK), Lumin (AU), Norval (UK), Tolvon (AU, HK^†, IE^†, NZ, SG^†), Tolmin (DK); where † indicates discontinued products) is a psychoactive drug of the tetracyclic antidepressant (TeCA) therapeutic family. It is classified as a noradrenergic and specific serotonergic antidepressant (NaSSA) and has antidepressant, anxiolytic (anti-anxiety), hypnotic (sedating), antiemetic (nausea and vomiting-attenuating), orexigenic (appetite-stimulating), and antihistamine effects.

It is not approved for use in the US, but its analogue, mirtazapine, is. Mianserin was the first antidepressant to reach the UK market that was less dangerous than the tricyclic antidepressants in overdose.

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Wikipedia