CYP2D6

CYP2D6
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2F9Q, 3QM4, 3TBG, 3TDA, 4WNT, 4WNU, 4WNV, 4WNW, 4XRY, 4XRZ
Identifiers
Aliases	CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1, cytochrome P450 family 2 subfamily D member 6, Cytochrome P450 2D6
External IDs	OMIM: 124030 HomoloGene: 133550 GeneCards: CYP2D6
Targeted by Drug
raubasine
Gene ontology Molecular function • iron ion binding • metal ion binding • monooxygenase activity • heme binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • drug binding • oxidoreductase activity • aromatase activity • oxygen binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Cellular component • organelle membrane • endoplasmic reticulum membrane • membrane • intracellular membrane-bounded organelle • endoplasmic reticulum • mitochondrion Biological process • steroid metabolic process • alkaloid metabolic process • coumarin metabolic process • lipid metabolic process • isoquinoline alkaloid metabolic process • alkaloid catabolic process • oxidative demethylation • drug catabolic process • heterocycle metabolic process • negative regulation of binding • drug metabolic process • monoterpenoid metabolic process • xenobiotic metabolic process • oxidation-reduction process • arachidonic acid metabolic process • negative regulation of cellular organofluorine metabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1565	n/a
Ensembl	n/a	n/a
UniProt	P10635	n/a
RefSeq (mRNA)	NM_000106 NM_001025161	n/a
RefSeq (protein)	NP_000097 NP_001020332	n/a
Location (UCSC)	Chr 22: 42.13 – 42.13 Mb	n/a
PubMed search		n/a

2F9Q, 3QM4, 3TBG, 3TDA, 4WNT, 4WNU, 4WNV, 4WNW, 4XRY, 4XRZ

1565

n/a

n/a

n/a

P10635

n/a

NM_000106
NM_001025161

n/a

NP_000097
NP_001020332

n/a

Cytochrome P450 2D6 is an enzyme that in humans is encoded by the CYP2D6 gene. CYP2D6 is primarily expressed in the liver. It is also highly expressed in areas of the CNS, including the substantia nigra.

CYP2D6, a member of the mixed-function oxidase system, is one of the most important enzymes involved in the metabolism of xenobiotics in the body. In particular, CYP2D6 is responsible for the metabolism and elimination of approximately 25% of clinically used drugs, via the addition or removal of certain functional groups – specifically, hydroxylation, demethylation, and dealkylation – at various points along a substrate's core structure. This enzyme also metabolizes several endogenous substances, such as hydroxytryptamines, neurosteroids, and both m-tyramine and p-tyramine which CYP2D6 metabolizes into dopamine in the brain and liver.

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Wikipedia