Serotonin

IUPAC name	3-(2-Aminoethyl)-1H-indol-5-ol
Synonyms	5-Hydroxytryptamine, Enteramine; Thrombocytin, 3-(β-Aminoethyl)-5-hydroxyindole, Thrombotonin
Abbreviation	5-HT
Sources	raphe nuclei, enterochromaffin cells
Targets	system-wide
Receptors	5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, 5-HT7
Agonists	SSRIs, MAOIs (indirectly)
Precursor	5-HTP
Synthesizing enzyme	Aromatic L-amino acid decarboxylase
Metabolizing enzyme	MAO
Database links
CAS Number	50-67-9 Y
PubChem	CID: 5202
IUPHAR/BPS	5
ChemSpider	5013 Y
KEGG	C00780 Y

Serotonin

Names
IUPAC names 5-Hydroxytryptamine or 3-(2-Aminoethyl)indol-5-ol
Other names 5-Hydroxytryptamine, 5-HT, Enteramine; Thrombocytin, 3-(β-Aminoethyl)-5-hydroxyindole, Thrombotonin
Identifiers
CAS Number	50-67-9 Y
3D model (Jmol)	Interactive image
ChEBI	CHEBI:28790 Y
ChEMBL	ChEMBL39 Y
ChemSpider	5013 Y
ECHA InfoCard	100.000.054
IUPHAR/BPS	5
KEGG	C00780 Y
MeSH	Serotonin
PubChem	5202
UNII	333DO1RDJY Y
InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2 Y Key: QZAYGJVTTNCVMB-UHFFFAOYSA-N Y InChI=1/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2 Key: QZAYGJVTTNCVMB-UHFFFAOYAX
SMILES c1cc2c(cc1O)c(c[nH]2)CCN
Properties
Chemical formula	C10H12N2O
Molar mass	176.215 g/mol
Appearance	White powder
Melting point	167.7 °C (333.9 °F; 440.8 K) 121–122 °C (ligroin)
Boiling point	416 ± 30 °C (at 760 Torr)
Solubility in water	slightly soluble
Acidity (pKa)	10.16 in water at 23.5 °C
Dipole moment	2.98 D
Hazards
Safety data sheet	External MSDS
Lethal dose or concentration (LD, LC):
LD50 (median dose)	750 mg/kg (subcutaneous, rat), 4500 mg/kg (intraperitoneal, rat), 60 mg/kg (oral, rat)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Y  (what is YN ?)
Infobox references

Serotonin (/ˌsɛrəˈtoʊnᵻn, ˌsɪərə-/) or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter. Biochemically derived from tryptophan, serotonin is primarily found in the gastrointestinal tract (GI tract), blood platelets, and the central nervous system (CNS) of animals, including humans. It is popularly thought to be a contributor to feelings of well-being and happiness.

Approximately 90% of the human body's total serotonin is located in the enterochromaffin cells in the GI tract, where it is used to regulate intestinal movements. The serotonin is secreted luminally and basolaterally which leads to increased serotonin uptake by circulating platelets and activation after stimulation, which gives increased stimulation of myenteric neurons and gastrointestinal motility. The remainder is synthesized in serotonergic neurons of the CNS, where it has various functions. These include the regulation of mood, appetite, and sleep. Serotonin also has some cognitive functions, including memory and learning. Modulation of serotonin at synapses is thought to be a major action of several classes of pharmacological antidepressants.