5-HT1A

HTR1A
Identifiers
Aliases	HTR1A, 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled, 5-HT-1A, 5-HT1A, 5HT1a, ADRB2RL1, ADRBRL1, G-21, PFMCD, 5-hydroxytryptamine receptor 1A
External IDs	OMIM: 109760 MGI: 96273 HomoloGene: 20148 GeneCards: HTR1A
Targeted by Drug
flibanserin, frovatriptan, LP-12, LP-211, LP-44, 1-naphthylpiperazine, 5-carboxamidotryptamine, pathogen, (+/-)-8-hydroxy-2-(di-N-propylamino)tetralin, aripiprazole, bmy-14802, cabergoline, clozapine, CP 93129, donitriptan, eletriptan, EMDT, flesinoxan, lisuride, lysergide, LY293284, LY334370, nafadotride, naratriptan, f-15599, ocaperidone, olanzapine, quetiapine, quinpirole, rizatriptan, ru-24969, S-14506, S-14671, spiroxatrine, sumatriptan, tandospirone, U92016A, xanomeline, zalospirone, zolmitriptan, apomorphine, bmy-7378 free base, brl-15572, bromocriptine, buspirone, fluparoxan, gr-127935, ipsapirone, pergolide, piribedil, roxindole, S-15535, sb-216641, terguride, vilazodone, vortioxetine, ziprasidone, (+)-butaclamol, chlorpromazine, cyamemazine, fluspirilene, haloperidol, iloperidone, Apiose, ketanserin, mesoridazine, metitepine, NAN 190, pimozide, pindolol, pipamperone, pizotyline, raclopride, repinotan, risperidone, ritanserin, robalzotan, sertindole, spiperone, thioridazine, tiospirone, WAY-100135, way-100635, yohimbine, zotepine
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity • G-protein coupled serotonin receptor activity • protein binding • serotonin binding • neurotransmitter receptor activity • receptor-receptor interaction Cellular component • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane Biological process • G-protein coupled receptor signaling pathway • regulation of behavior • behavior • vasoconstriction • adenylate cyclase-inhibiting serotonin receptor signaling pathway • serotonin metabolic process • behavioral fear response • regulation of dopamine metabolic process • regulation of serotonin secretion • exploration behavior • serotonin receptor signaling pathway • positive regulation of cell proliferation • regulation of hormone secretion • cell proliferation • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3350	15550
Ensembl	ENSG00000178394	ENSMUSG00000021721
UniProt	P08908	Q64264
RefSeq (mRNA)	NM_000524	NM_008308
RefSeq (protein)	NP_000515	NP_032334.2 NP_032334
Location (UCSC)	Chr 5: 63.96 – 63.96 Mb	Chr 13: 105.44 – 105.45 Mb
PubMed search

3350

15550

ENSG00000178394

ENSMUSG00000021721

P08908

Q64264

NM_000524

NM_008308

NP_000515

NP_032334.2
NP_032334

The 5-HT_1A receptor is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). It is a G protein-coupled receptor (GPCR) that is coupled to G_i/G_o and mediates inhibitory neurotransmission. HTR1A denotes the human gene encoding for the receptor.

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