CXC chemokine receptors
| CXCR1 | |
|---|---|
| Identifiers | |
| Symbol | IL8RA |
| Entrez | 3577 |
| OMIM | 146929 |
| RefSeq | NM_000634 |
| UniProt | P25024 |
| Other data | |
| Locus | Chr. 2 q35 |
| CXCR2 | |
|---|---|
| Identifiers | |
| Symbol | IL8RB |
| Entrez | 3579 |
| OMIM | 146928 |
| RefSeq | NM_001557 |
| UniProt | P25025 |
| Other data | |
| Locus | Chr. 2 q35 |
| CXCR3 | |
|---|---|
| Identifiers | |
| Symbol | CXCR3 |
| Entrez | 2833 |
| OMIM | 300574 |
| RefSeq | NM_001504 |
| UniProt | P49682 |
| Other data | |
| Locus | Chr. X q13 |
| CXCR4 | |
|---|---|
| Identifiers | |
| Symbol | CXCR4 |
| Entrez | 7852 |
| OMIM | 162643 |
| RefSeq | NM_001008540 |
| UniProt | P61073 |
| Other data | |
| Locus | Chr. 2 q21 |
| CXCR5 | |
|---|---|
| Identifiers | |
| Symbol | BLR1 |
| Entrez | 643 |
| OMIM | 601613 |
| RefSeq | NM_001716 |
| UniProt | P32302 |
| Other data | |
| Locus | Chr. 11 q23 |
| CXCR6 | |
|---|---|
| Identifiers | |
| Symbol | CXCR6 |
| Entrez | 10663 |
| OMIM | 605163 |
| RefSeq | NM_006564 |
| UniProt | O00574 |
| Other data | |
| Locus | Chr. 3 p21 |
| CXCR7 | |
|---|---|
| Identifiers | |
| Symbol | CMKOR1 |
| Alt. symbols | RDC1 |
| Entrez | 57007 |
| RefSeq | NM_020311 |
| UniProt | P25106 |
| Other data | |
| Locus | Chr. 2 q37 |
CXC chemokine receptors are integral membrane proteins that specifically bind and respond to cytokines of the CXC chemokine family. They represent one subfamily of chemokine receptors, a large family of G protein-linked receptors that are known as seven transmembrane (7-TM) proteins, since they span the cell membrane seven times. There are currently seven known CXC chemokine receptors in mammals, named CXCR1 through CXCR7.
CXCR1 and CXCR2 are closely related receptors that recognize CXC chemokines that possess an E-L-R amino acid motif immediately adjacent to their CXC motif. CXCL8 (otherwise known as interleukin-8) and CXCL6 can both bind CXCR1 in humans, while all other ELR-positive chemokines, such as CXCL1 to CXCL7 bind only CXCR2. They are both expressed on the surface of neutrophils in mammals.
CXCR3 is expressed predominantly on T cells (T lymphocytes), and also on other lymphocytes [some B cells (B lymphocytes) and NK cells] and is highly induced following cell activation. There are two isoforms, CXCR3-A and CXCR3-B. It has three highly related ligands in mammals, CXCL9, CXCL10 and CXCL11.
CXCR4 (also known as fusin) is the receptor for a chemokine known as CXCL12 (or SDF-1) and, as with CCR5, is utilized by HIV-1 to gain entry into target cells. This receptor has a wide cellular distribution, with expression on most immature and mature hematopoietic cell types (e.g. neutrophils, monocytes, T and B cells, dendritic cells, Langerhans cells and macrophages). In addition, CXCR4 can also be found on vascular endothelial cells and neuronal/nerve cells.
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Wikipedia