CXCL1

CXCL1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1MGS, 1MSG, 1MSH
Identifiers
Aliases	CXCL1, FSP, GRO1, GROa, MGSA, MGSA-a, NAP-3, SCYB1, C-X-C motif chemokine ligand 1
External IDs	OMIM: 155730 HomoloGene: 136748 GeneCards: CXCL1
Gene ontology Molecular function • receptor binding • growth factor activity • cytokine activity • enzyme activator activity • CXCR chemokine receptor binding • chemokine activity Cellular component • extracellular region • extracellular space • specific granule lumen • tertiary granule lumen Biological process • negative regulation of cell proliferation • intracellular signal transduction • response to lipopolysaccharide • signal transduction • G-protein coupled receptor signaling pathway • nervous system development • positive regulation of neutrophil chemotaxis • cell proliferation • actin cytoskeleton organization • immune response • chemokine-mediated signaling pathway • positive regulation of catalytic activity • cell chemotaxis • chemotaxis • defense response • inflammatory response • neutrophil degranulation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2919	n/a
Ensembl	ENSG00000163739	n/a
UniProt	P09341	n/a
RefSeq (mRNA)	NM_001511	n/a
RefSeq (protein)	NP_001502	n/a
Location (UCSC)	Chr 4: 73.87 – 73.87 Mb	n/a
PubMed search		n/a

1MGS, 1MSG, 1MSH

2919

n/a

ENSG00000163739

n/a

P09341

n/a

NM_001511

n/a

NP_001502

n/a

The chemokine (C-X-C motif) ligand 1 (CXCL1) is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GROα, KC, neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-α). In humans, this protein is encoded by the CXCL1 gene.

CXCL1 is secreted by human melanoma cells, has mitogenic properties and is implicated in melanoma pathogenesis. CXCL1 is expressed by macrophages, neutrophils and epithelial cells, and has neutrophil chemoattractant activity. CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, arteriogenesis, inflammation, wound healing, and tumorigenesis. This chemokine elicits its effects by signaling through the chemokine receptor CXCR2. The gene for CXCL1 is located on human chromosome 4 amongst genes for other CXC chemokines. An initial study in mice showed evidence that CXCL1 decreased the severity of multiple sclerosis and may offer a neuro-protective function.

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