Chromosome 4

Chromosome 4 (human)
Human chromosome 4 pair after G-banding. One is from mother, one is from father.
Chromosome 4 pair in human male karyogram.
Features
Length (bp)	190,214,555 bp
No. of genes	731 (HGNC) 746 (Ensembl) 769 (NCBI)
Type	Autosome
Centromere position	Submetacentric (50.0 Mbp)
External map viewers
Ensembl	Chromosome 4
Entrez	Chromosome 4
NCBI	Chromosome 4
UCSC	Chromosome 4
Full DNA sequences
RefSeq	NC_000004 (FASTA)
GenBank	CM000666 (FASTA)

Chromosome 4 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 4 spans more than 186 million base pairs (the building material of DNA) and represents between 6 and 6.5 percent of the total DNA in cells.

The chromosome is ~191 megabases in length. In a 2012 paper, seven hundred and fifty seven protein encoding genes were identified on this chromosome. Two-hundred and eleven (27.9%) of these coding sequences did not have any experimental evidence at the protein level, in 2012. Two-hundred and seventy one appear to be membrane proteins. Fifty-four have been classified as cancer associated proteins.

The following are gene count estimates of human chromosome 4. Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies.

When simply saying "number of genes", in most cases, it refers only to "number of protein-coding genes".

The following are some of the genes located on chromosome 4:

The following are some of the diseases related to genes located on chromosome 4: