IL8RA

CXCR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ILP, 1ILQ, 2LNL
Identifiers
Aliases	CXCR1, C-C, C-C-CKR-1, CD128, CD181, CDw128a, CKR-1, CMKAR1, IL8R1, IL8RA, IL8RBA, Interleukin 8 receptor, C-X-C motif chemokine receptor 1
External IDs	MGI: 2448715 HomoloGene: 68074 GeneCards: CXCR1
Gene ontology Molecular function • C-X-C chemokine receptor activity • interleukin-8 binding • G-protein coupled receptor activity • chemokine receptor activity • interleukin-8 receptor activity • signal transducer activity Cellular component • integral component of membrane • plasma membrane • membrane • secretory granule membrane Biological process • chemotaxis • G-protein coupled receptor signaling pathway • cell surface receptor signaling pathway • receptor internalization • inflammatory response • dendritic cell chemotaxis • signal transduction • chemokine-mediated signaling pathway • interleukin-8-mediated signaling pathway • neutrophil degranulation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3577	227288
Ensembl	ENSG00000163464	ENSMUSG00000048480
UniProt	P25024	Q810W6
RefSeq (mRNA)	NM_000634	NM_178241
RefSeq (protein)	NP_000625	NP_839972.1 NP_839972
Location (UCSC)	Chr 2: 218.16 – 218.17 Mb	Chr 1: 74.19 – 74.19 Mb
PubMed search

1ILP, 1ILQ, 2LNL

3577

227288

ENSG00000163464

ENSMUSG00000048480

P25024

Q810W6

NM_000634

NM_178241

NP_000625

NP_839972.1
NP_839972

Interleukin 8 receptor, alpha is a chemokine receptor. This name and the corresponding gene symbol IL8RA have been replaced by the HGNC approved name C-X-C motif chemokine receptor 1 and the approved symbol CXCR1. It has also been designated as CD181 (cluster of differentiation 181). The IUPHAR Committee on Receptor Nomenclature and Drug Classification use the HGNC recommended name, CXCR1.

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein-activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, and IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Stimulation of CXCR1 in neutrophils by its primary ligand, Interleukin 8, leads to neutrophil chemotaxis and activation.

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Wikipedia