IL8RB

CXCR2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4Q3H
Identifiers
Aliases	CXCR2, CD182, CDw128b, CMKAR2, IL8R2, IL8RA, IL8RB, Interleukin 8 receptor, beta, C-X-C motif chemokine receptor 2
External IDs	MGI: 105303 HomoloGene: 10439 GeneCards: CXCR2
Gene ontology Molecular function • C-X-C chemokine receptor activity • interleukin-8 binding • G-protein coupled receptor activity • signal transducer activity • protein binding • interleukin-8 receptor activity Cellular component • integral component of membrane • membrane • mast cell granule • plasma membrane • integral component of plasma membrane • intracellular • cell surface • secretory granule membrane Biological process • G-protein coupled receptor signaling pathway • neutrophil activation • receptor internalization • dendritic cell chemotaxis • chemotaxis • cellular defense response • phospholipase C-activating G-protein coupled receptor signaling pathway • cell surface receptor signaling pathway • positive regulation of cell proliferation • inflammatory response • signal transduction • interleukin-8-mediated signaling pathway • chemokine-mediated signaling pathway • neutrophil chemotaxis • neutrophil degranulation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3579	12765
Ensembl	ENSG00000180871	ENSMUSG00000026180
UniProt	P25025	P35343
RefSeq (mRNA)	NM_001168298 NM_001557	NM_009909
RefSeq (protein)	NP_001161770 NP_001548	NP_034039.1 NP_034039
Location (UCSC)	Chr 2: 218.13 – 218.14 Mb	Chr 1: 74.15 – 74.16 Mb
PubMed search

4Q3H

3579

12765

ENSG00000180871

ENSMUSG00000026180

P25025

P35343

NM_001168298
NM_001557

NM_009909

NP_001161770
NP_001548

NP_034039.1
NP_034039

Interleukin 8 receptor, beta is a chemokine receptor. IL8RB is also known as CXCR2, and CXCR2 is now the IUPHAR Committee on Receptor Nomenclature and Drug classification-recommended name.

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein-activated second messenger system (G_i/o-coupled). This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. In addition, it binds ligands CXCL2, CXCL3, and CXCL5.

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Wikipedia