CXCL5

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
2MGS

Identifiers

Aliases

CXCL5, ENA-78, SCYB5, C-X-C motif chemokine ligand 5

External IDs

OMIM: 600324 HomoloGene: 88672 GeneCards: CXCL5

Gene ontology
Molecular function	• CXCR chemokine receptor binding • cytokine activity • chemokine activity
Cellular component	• extracellular region • extracellular space
Biological process	• positive regulation of cell proliferation • inflammatory response • G-protein coupled receptor signaling pathway • response to lipopolysaccharide • signal transduction • cell-cell signaling • immune response • chemokine-mediated signaling pathway • cell chemotaxis • neutrophil mediated immunity • chemotaxis • defense response • positive regulation of neutrophil chemotaxis
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


6374


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Ensembl


ENSG00000163735


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UniProt


P42830


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RefSeq (mRNA)


NM_002994


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RefSeq (protein)


NP_002985


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Location (UCSC)

Chr 4: 74 – 74 Mb

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PubMed search

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C-X-C motif chemokine 5 (CXCL5 or ENA78) is a protein that in humans is encoded by the CXCL5 gene.

The protein encoded by this gene, CXCL5 is a small cytokine belonging to the CXC chemokine family that is also known as epithelial-derived neutrophil-activating peptide 78 (ENA-78). It is produced following stimulation of cells with the inflammatory cytokines interleukin-1 or tumor necrosis factor-alpha. Expression of CXCL5 has also been observed in eosinophils, and can be inhibited with the type II interferon IFN-γ. This chemokine stimulates the chemotaxis of neutrophils possessing angiogenic properties. It elicits these effects by interacting with the cell surface chemokine receptor CXCR2. The gene for CXCL5 is encoded on four exons and is located on human chromosome 4 amongst several other CXC chemokine genes. CXCL5 has been implicated in connective tissue remodelling. CXCL5 has been also described to regulate neutrophil homeostasis.

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Wikipedia