Interleukin-8

CXCL8
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3IL8, 1ICW, 1IKL, 1IKM, 1IL8, 1ILP, 1ILQ, 1QE6, 1ROD, 2IL8, 4XDX
Identifiers
Aliases	CXCL8, chemokine (C-X-C motif) ligand 8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1, IL8, C-X-C motif chemokine ligand 8, Interleukin-8
External IDs	OMIM: 146930 HomoloGene: 47937 GeneCards: CXCL8
Gene ontology Molecular function • cytokine activity • protein binding • interleukin-8 receptor binding • chemokine activity Cellular component • extracellular region • intracellular • extracellular space Biological process • G-protein coupled receptor signaling pathway • movement of cell or subcellular component • intracellular signal transduction • chemokine-mediated signaling pathway • cellular response to tumor necrosis factor • receptor internalization • cellular response to fibroblast growth factor stimulus • response to endoplasmic reticulum stress • positive regulation of angiogenesis • regulation of single stranded viral RNA replication via double stranded DNA intermediate • PERK-mediated unfolded protein response • induction of positive chemotaxis • chemotaxis • regulation of cell adhesion • immune response • cell cycle arrest • cellular response to interleukin-1 • angiogenesis • positive regulation of neutrophil chemotaxis • inflammatory response • negative regulation of G-protein coupled receptor protein signaling pathway • response to molecule of bacterial origin • cellular response to lipopolysaccharide • embryonic digestive tract development • signal transduction • negative regulation of cell proliferation • calcium-mediated signaling • regulation of entry of bacterium into host cell • defense response • neutrophil chemotaxis • neutrophil activation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3576	n/a
Ensembl	ENSG00000169429	n/a
UniProt	P10145	n/a
RefSeq (mRNA)	NM_000584	n/a
RefSeq (protein)	NP_000575	n/a
Location (UCSC)	Chr 4: 73.74 – 73.74 Mb	n/a
PubMed search		n/a

3IL8, 1ICW, 1IKL, 1IKM, 1IL8, 1ILP, 1ILQ, 1QE6, 1ROD, 2IL8, 4XDX

3576

n/a

ENSG00000169429

n/a

P10145

n/a

NM_000584

n/a

NP_000575

n/a

Interleukin 8 (IL8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells. Endothelial cells store IL-8 in their storage vesicles, the Weibel-Palade bodies. In humans, the interleukin-8 protein is encoded by the IL8 gene. IL-8 is initially produced as a precursor peptide of 99 amino acids long which then undergoes cleavage to create several active IL-8 isoforms. In culture, a 72 amino acid peptide is the major form secreted by macrophages.

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