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Interleukin-8

CXCL8
IL8 Solution Structure.rsh.png
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases CXCL8, chemokine (C-X-C motif) ligand 8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1, IL8, C-X-C motif chemokine ligand 8, Interleukin-8
External IDs OMIM: 146930 HomoloGene: 47937 GeneCards: CXCL8
RNA expression pattern
PBB GE IL8 202859 x at.png

PBB GE IL8 211506 s at.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000584

n/a

RefSeq (protein)

NP_000575

n/a

Location (UCSC) Chr 4: 73.74 – 73.74 Mb n/a
PubMed search n/a

3IL8, 1ICW, 1IKL, 1IKM, 1IL8, 1ILP, 1ILQ, 1QE6, 1ROD, 2IL8, 4XDX

NM_000584

n/a

NP_000575

n/a

Interleukin 8 (IL8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells. Endothelial cells store IL-8 in their storage vesicles, the Weibel-Palade bodies. In humans, the interleukin-8 protein is encoded by the IL8 gene. IL-8 is initially produced as a precursor peptide of 99 amino acids long which then undergoes cleavage to create several active IL-8 isoforms. In culture, a 72 amino acid peptide is the major form secreted by macrophages.


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Wikipedia

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