CXCR6

CXCR6
Identifiers
Aliases	CXCR6, BONZO, CD186, STRL33, TYMSTR, C-X-C motif chemokine receptor 6
External IDs	MGI: 1934582 HomoloGene: 38197 GeneCards: CXCR6
Gene ontology Molecular function • C-X-C chemokine receptor activity • C-X-C chemokine binding • G-protein coupled receptor activity • chemokine receptor activity • signal transducer activity • coreceptor activity Cellular component • integral component of membrane • plasma membrane • integral component of plasma membrane • membrane Biological process • viral genome replication • chemotaxis • chemokine-mediated signaling pathway • G-protein coupled receptor signaling pathway • inflammatory response • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10663	80901
Ensembl	ENSG00000172215	ENSMUSG00000048521
UniProt	O00574	Q9EQ16
RefSeq (mRNA)	NM_006564	NM_030712
RefSeq (protein)	NP_006555	NP_109637.3 NP_109637
Location (UCSC)	Chr 3: 45.94 – 45.95 Mb	Chr 9: 123.81 – 123.81 Mb
PubMed search

10663

80901

ENSG00000172215

ENSMUSG00000048521

O00574

Q9EQ16

NM_006564

NM_030712

NP_006555

NP_109637.3
NP_109637

C-X-C chemokine receptor type 6 is a protein that in humans is encoded by the CXCR6 gene. CXCR6 has also recently been designated CD186 (cluster of differentiation 186).

CXCR6 has been identified as an entry coreceptor used by HIV-1 and SIV to enter target cells, in conjunction with CD4. It is a minor coreceptor for HIV-1, nearly all strains of which use CCR5 and/or CXCR4. Most SIV strains can use CXCR6 and recent evidence suggests that in monkeys that serve as the natural hosts of SIV, CXCR6 may be a major coreceptor. CXCR6 was previously known as "Bonzo" and "STRL33" in the HIV/SIV field.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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