CXCR5

CXCR5
Identifiers
Aliases	CXCR5, BLR1, CD185, MDR15, C-X-C motif chemokine receptor 5, C-X-C chemokine receptor type 5
External IDs	OMIM: 601613 MGI: 103567 HomoloGene: 1298 GeneCards: CXCR5
Genetically Related Diseases
inflammatory bowel disease, multiple sclerosis
Gene ontology Molecular function • C-X-C chemokine receptor activity • G-protein coupled receptor activity • protein binding • signal transducer activity Cellular component • integral component of membrane • plasma membrane • integral component of plasma membrane • membrane Biological process • positive regulation of cytokinesis • chemokine-mediated signaling pathway • chemotaxis • B cell activation • G-protein coupled receptor signaling pathway • movement of cell or subcellular component • lymph node development • immune response • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	643	12145
Ensembl	ENSG00000160683	ENSMUSG00000047880
UniProt	P32302	Q04683
RefSeq (mRNA)	NM_032966 NM_001716	NM_007551
RefSeq (protein)	NP_001707 NP_116743	NP_031577.2 NP_031577
Location (UCSC)	Chr 11: 118.88 – 118.9 Mb	Chr 9: 44.51 – 44.56 Mb
PubMed search

643

12145

ENSG00000160683

ENSMUSG00000047880

P32302

Q04683

NM_032966
NM_001716

NM_007551

NP_001707
NP_116743

NP_031577.2
NP_031577

C-X-C chemokine receptor type 5 (CXC-R5) also known as CD185 (cluster of differentiation 185) or Burkitt lymphoma receptor 1 (BLR1) is a G protein-coupled seven transmembrane receptor for chemokine CXCL13 (also known as BLC) and belongs to the CXC chemokine receptor family. It enables T cells to migrate to lymph node B cell zones. In humans, the CXC-R5 protein is encoded by the CXCR5 gene.

The BLR1 / CXCR5 gene is specifically expressed in Burkitt's lymphoma and lymphatic tissues, such as follicles in lymph nodes as well as in spleen. The gene plays an essential role in B cell migration. Recently, it was shown that CXCR5 overexpression in breast cancer patients highly correlates with lymph node metastases, and elevated CXCR5 expression may contribute to abnormal cell survival and migration in breast tumors that lack functional p53 protein. Minor allele of SNP rs630923, located in the area of CXCR5 gene promoter and associated with the risk of multiple sclerosis, is responsible for appearance of MEF2C-binding site resulted in reduced CXCR5 gene promoter activity in B-cells during activation, that could lead to decreased autoimmune response

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