MEF2C

MEF2C

Protein MEF2C PDB 1c7u.png

Identifiers

MEF2C, C5DELq14.3, DEL5q14.3, myocyte enhancer factor 2C

External IDs

MGI: 99458 HomoloGene: 31087 GeneCards: MEF2C

Gene ontology
Molecular function	• protein dimerization activity • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • histone deacetylase binding • transcription factor activity, RNA polymerase II core promoter sequence-specific • core promoter sequence-specific DNA binding • transcription regulatory region DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • miRNA binding • HMG box domain binding • activating transcription factor binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding • RNA polymerase II distal enhancer sequence-specific DNA binding • AT DNA binding • chromatin binding • core promoter proximal region sequence-specific DNA binding • protein binding • DNA binding • sequence-specific DNA binding • protein heterodimerization activity • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Cellular component	• nucleus • nuclear speck • intracellular membrane-bounded organelle • nucleoplasm • protein complex • cytoplasm • postsynapse
Biological process	• negative regulation of neuron apoptotic process • embryonic skeletal system morphogenesis • myotube differentiation • positive regulation of skeletal muscle tissue development • cell morphogenesis involved in neuron differentiation • positive regulation of muscle cell differentiation • regulation of synapse assembly • muscle organ development • outflow tract morphogenesis • monocyte differentiation • sinoatrial valve morphogenesis • negative regulation of ossification • heart looping • positive regulation of skeletal muscle cell differentiation • blood vessel remodeling • cellular response to drug • blood vessel development • positive regulation of cardiac muscle cell proliferation • humoral immune response • positive regulation of alkaline phosphatase activity • negative regulation of epithelial cell proliferation • regulation of synaptic transmission, glutamatergic • melanocyte differentiation • apoptotic process • B cell receptor signaling pathway • cellular response to calcium ion • cellular response to transforming growth factor beta stimulus • renal tubule morphogenesis • nephron tubule epithelial cell differentiation • cell fate commitment • cardiac ventricle formation • regulation of transcription, DNA-templated • cardiac muscle cell differentiation • regulation of neuron apoptotic process • response to virus • platelet formation • neuron development • smooth muscle cell differentiation • positive regulation of protein homodimerization activity • negative regulation of gene expression • transcription, DNA-templated • cellular response to trichostatin A • positive regulation of transcription, DNA-templated • heart development • epithelial cell proliferation involved in renal tubule morphogenesis • cardiac muscle hypertrophy in response to stress • positive regulation of B cell proliferation • positive regulation of neuron differentiation • excitatory postsynaptic potential • learning or memory • positive regulation of macrophage apoptotic process • positive regulation of cardiac muscle cell differentiation • cellular response to parathyroid hormone stimulus • primary heart field specification • secondary heart field specification • regulation of dendritic spine development • regulation of germinal center formation • palate development • cell differentiation • chondrocyte differentiation • positive regulation of bone mineralization • neural crest cell differentiation • neuron migration • B cell homeostasis • negative regulation of transcription from RNA polymerase II promoter • endochondral ossification • regulation of neurotransmitter secretion • cellular response to fluid shear stress • nervous system development • regulation of synaptic plasticity • regulation of NMDA receptor activity • muscle cell fate determination • positive regulation of osteoblast differentiation • regulation of synaptic activity • osteoblast differentiation • neuron differentiation • regulation of sarcomere organization • skeletal muscle cell differentiation • positive regulation of behavioral fear response • glomerulus morphogenesis • germinal center formation • positive regulation of cell proliferation in bone marrow • MAPK cascade • regulation of AMPA receptor activity • multicellular organism development • B cell proliferation • positive regulation of gene expression • positive regulation of myoblast differentiation • cartilage morphogenesis • embryonic viscerocranium morphogenesis • ventricular cardiac muscle cell differentiation • cellular response to lipopolysaccharide • skeletal muscle tissue development • regulation of megakaryocyte differentiation • positive regulation of transcription from RNA polymerase II promoter • transdifferentiation • cellular response to organic cyclic compound • cellular response to retinoic acid • cellular response to glucose stimulus • response to vitamin E • dentate gyrus development • transcription from RNA polymerase II promoter • response to nutrient levels
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE MEF2C 209200 at fs.png

PBB GE MEF2C 207968 s at fs.png

PBB GE MEF2C 209199 s at fs.png

More reference expression data

Orthologs

Species

Human

Mouse


4208


17260


ENSG00000081189


ENSMUSG00000005583


Q06413


Q8CFN5

RefSeq (mRNA)

NM_001131005 NM_001193347 NM_001193348 NM_001193349 NM_001193350
NM_001308002 NM_002397


NM_001170537 NM_025282

RefSeq (protein)

NP_001124477 NP_001180276 NP_001180277 NP_001180278 NP_001180279
NP_001294931 NP_002388 NP_001294931.1

NP_079558.1 NP_001164008 NP_001334493 NP_001334495 NP_001334496
NP_001334497 NP_001334498 NP_001334500 NP_001334501 NP_001334502 NP_001334503 NP_001334504 NP_001334505 NP_001334506 NP_001334507 NP_001334508 NP_001334509 NP_001334510 NP_079558

Location (UCSC)

Chr 5: 88.72 – 88.9 Mb

Chr 13: 83.5 – 83.67 Mb

PubMed search

ENSG00000081189

ENSMUSG00000005583

NM_001308002
NM_002397

NM_001170537
NM_025282

NP_001294931
NP_002388
NP_001294931.1

NP_001334497
NP_001334498
NP_001334500
NP_001334501
NP_001334502
NP_001334503
NP_001334504
NP_001334505
NP_001334506
NP_001334507
NP_001334508
NP_001334509
NP_001334510
NP_079558

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Wikipedia

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