CXCL13

CXCL13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4ZAI, 5CBA, 5CBE
Identifiers
Aliases	CXCL13, ANGIE, ANGIE2, BCA-1, BCA1, BLC, BLR1L, SCYB13, C-X-C motif chemokine ligand 13
External IDs	OMIM: 605149 MGI: 1888499 HomoloGene: 48431 GeneCards: CXCL13
Gene ontology Molecular function • receptor agonist activity • CCR10 chemokine receptor binding • cytokine activity • heparin binding • CXCR3 chemokine receptor binding • chemokine activity • protein heterodimerization activity • fibroblast growth factor binding • CXCR5 chemokine receptor binding Cellular component • extracellular region • cell • extracellular space Biological process • G-protein coupled receptor signaling pathway • positive regulation of cell-cell adhesion mediated by integrin • B cell chemotaxis • activation of GTPase activity • chemokine-mediated signaling pathway • positive regulation of cytosolic calcium ion concentration • cell-cell signaling • germinal center formation • positive regulation of integrin activation • regulation of angiogenesis • chemotaxis • endothelial cell chemotaxis to fibroblast growth factor • regulation of humoral immune response • lymphocyte chemotaxis across high endothelial venule • cell surface receptor signaling pathway • response to lipopolysaccharide • regulation of cell proliferation • defense response to bacterium • negative regulation of endothelial cell chemotaxis to fibroblast growth factor • positive regulation of T cell chemotaxis • immune response • inflammatory response • lymph node development • chronic inflammatory response • B cell chemotaxis across high endothelial venule • defense response • positive regulation of receptor activity • killing of cells of other organism • antimicrobial humoral immune response mediated by antimicrobial peptide Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10563	55985
Ensembl	ENSG00000156234	ENSMUSG00000023078
UniProt	O43927	O55038
RefSeq (mRNA)	NM_006419	NM_018866
RefSeq (protein)	NP_006410	NP_061354.1 NP_061354
Location (UCSC)	Chr 4: 77.51 – 77.61 Mb	Chr 5: 95.96 – 95.96 Mb
PubMed search

4ZAI, 5CBA, 5CBE

10563

55985

ENSG00000156234

ENSMUSG00000023078

O43927

O55038

NM_006419

NM_018866

NP_006410

NP_061354.1
NP_061354

chemokine (C-X-C motif) ligand 13 (CXCL13), also known as B lymphocyte chemoattractant (BLC) or B cell-attracting chemokine 1 (BCA-1), is a protein ligand that in humans is encoded by the CXCL13 gene.

CXCL13 is a small cytokine belonging to the CXC chemokine family. As its name suggests, this chemokine is selectively chemotactic for B cells belonging to both the B-1 and B-2 subsets, and elicits its effects by interacting with chemokine receptor CXCR5. CXCL13 and its receptor CXCR5 control the organization of B cells within follicles of lymphoid tissues. and is expressed highly in the liver, spleen, lymph nodes, and gut of humans. The gene for CXCL13 is located on human chromosome 4 in a cluster of other CXC chemokines.

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