CXCL11

CXCL11
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1RJT
Identifiers
Aliases	CXCL11, H174, I-TAC, IP-9, IP9, SCYB11, SCYB9B, b-R1, C-X-C motif chemokine ligand 11
External IDs	OMIM: 604852 HomoloGene: 3944 GeneCards: CXCL11
Gene ontology Molecular function • chemokine activity • cytokine activity • heparin binding • protein binding • CXCR3 chemokine receptor binding Cellular component • extracellular region • extracellular space • cell Biological process • chemotaxis • positive regulation of leukocyte chemotaxis • G-protein coupled receptor signaling pathway • T cell chemotaxis • chemokine-mediated signaling pathway • response to lipopolysaccharide • cell-cell signaling • positive regulation of release of sequestered calcium ion into cytosol • positive regulation of cAMP-mediated signaling • regulation of cell proliferation • immune response • positive regulation of cAMP metabolic process • signal transduction • defense response • inflammatory response • killing of cells of other organism • antimicrobial humoral immune response mediated by antimicrobial peptide Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6373	n/a
Ensembl	ENSG00000169248	n/a
UniProt	O14625	n/a
RefSeq (mRNA)	NM_005409 NM_001302123	n/a
RefSeq (protein)	NP_001289052 NP_005400	n/a
Location (UCSC)	Chr 4: 76.03 – 76.04 Mb	n/a
PubMed search		n/a

1RJT

6373

n/a

ENSG00000169248

n/a

O14625

n/a

NM_005409
NM_001302123

n/a

NP_001289052
NP_005400

n/a

C-X-C motif chemokine 11 (CXCL11) is a protein that in humans is encoded by the CXCL11 gene.

C-X-C motif chemokine 11 is a small cytokine belonging to the CXC chemokine family that is also called Interferon-inducible T-cell alpha chemoattractant (I-TAC) and Interferon-gamma-inducible protein 9 (IP-9). It is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in small intestine, placenta and prostate.

Gene expression of CXCL11 is strongly induced by IFN-γ and IFN-β, and weakly induced by IFN-α. This chemokine elicits its effects on its target cells by interacting with the cell surface chemokine receptor CXCR3, with a higher affinity than do the other ligands for this receptor, CXCL9 and CXCL10. CXCL11 is chemotactic for activated T cells. Its gene is located on human chromosome 4 along with many other members of the CXC chemokine family.

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