CXCL9

CXCL9
Identifiers
Aliases	CXCL9, CMK, Humig, MIG, SCYB9, crg-10, C-X-C motif chemokine ligand 9
External IDs	OMIM: 601704 HomoloGene: 1813 GeneCards: CXCL9
Gene ontology Molecular function • cytokine activity • CXCR3 chemokine receptor binding • chemokine activity • protein binding Cellular component • extracellular region • external side of plasma membrane • extracellular space Biological process • G-protein coupled receptor signaling pathway • positive regulation of cAMP metabolic process • chemokine-mediated signaling pathway • cell-cell signaling • positive regulation of release of sequestered calcium ion into cytosol • positive regulation of cAMP-mediated signaling • chemotaxis • positive regulation of leukocyte chemotaxis • cellular defense response • positive regulation of myoblast fusion • response to lipopolysaccharide • regulation of cell proliferation • positive regulation of myoblast differentiation • defense response to virus • immune response • signal transduction • defense response • inflammatory response • T cell chemotaxis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4283	n/a
Ensembl	ENSG00000138755	n/a
UniProt	Q07325	n/a
RefSeq (mRNA)	NM_002416	n/a
RefSeq (protein)	NP_002407	n/a
Location (UCSC)	Chr 4: 76 – 76.01 Mb	n/a
PubMed search		n/a

4283

n/a

ENSG00000138755

n/a

Q07325

n/a

NM_002416

n/a

NP_002407

n/a

Chemokine (C-X-C motif) ligand 9 (CXCL9) is a small cytokine belonging to the CXC chemokine family that is also known as Monokine induced by gamma interferon (MIG). CXCL9 is a T-cell chemoattractant, which is induced by IFN-γ. It is closely related to two other CXC chemokines called CXCL10 and CXCL11, whose genes are located near the gene for CXCL9 on human chromosome 4. CXCL9, CXCL10 and CXCL11 all elicit their chemotactic functions by interacting with the chemokine receptor CXCR3.

Neutrophil collagenase/matrix metalloproteinase 8 (MMP-8) degrades CXCL9 and cleaves CXCL10 at two positions.

Gelatinase B/matrix metalloproteinase 9 (MMP-9) degrades CXCL10 and cleaves CXCL9 at three different sites in its extended carboxy-terminal region.

CXCL9, -10, -11 have proven to be valid biomarkers for the development of heart failure and left ventricular dysfunction, suggesting an underlining pathophysiological relation between levels of these chemokines and the development of adverse cardiac remodeling.

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Wikipedia