CXCL10

CXCL10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1O80, 1LV9, 1O7Y, 1O7Z
Identifiers
Aliases	CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1, C-X-C motif chemokine ligand 10, C-X-C motif chemokine 10
External IDs	OMIM: 147310 MGI: 1352450 HomoloGene: 1203 GeneCards: CXCL10
Gene ontology Molecular function • cytokine activity • heparin binding • CXCR3 chemokine receptor binding • chemokine activity • protein binding • cAMP-dependent protein kinase regulator activity • receptor binding Cellular component • extracellular region • external side of plasma membrane • extracellular space Biological process • G-protein coupled receptor signaling pathway • regulation of endothelial tube morphogenesis • negative regulation of myoblast differentiation • cellular response to heat • response to vitamin D • positive regulation of cAMP metabolic process • positive regulation of cell migration • T cell chemotaxis • chemokine-mediated signaling pathway • cell-cell signaling • response to virus • muscle organ development • positive regulation of monocyte chemotaxis • positive regulation of release of sequestered calcium ion into cytosol • endothelial cell activation • positive regulation of cAMP-mediated signaling • regulation of T cell chemotaxis • blood circulation • chemotaxis • positive regulation of leukocyte chemotaxis • cell surface receptor signaling pathway • response to lipopolysaccharide • negative regulation of myoblast fusion • defense response to virus • regulation of cell proliferation • immune response • positive regulation of cell proliferation • response to auditory stimulus • negative regulation of angiogenesis • response to cold • cellular response to lipopolysaccharide • response to gamma radiation • positive regulation of T cell migration • signal transduction • positive regulation of transcription from RNA polymerase II promoter • regulation of protein kinase activity • defense response • inflammatory response Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3627	15945
Ensembl	ENSG00000169245	ENSMUSG00000034855
UniProt	P02778	P17515
RefSeq (mRNA)	NM_001565	NM_021274
RefSeq (protein)	NP_001556	NP_067249.1 NP_067249
Location (UCSC)	Chr 4: 76.02 – 76.02 Mb	Chr 5: 92.35 – 92.35 Mb
PubMed search

1O80, 1LV9, 1O7Y, 1O7Z

3627

15945

ENSG00000169245

ENSMUSG00000034855

P02778

P17515

NM_001565

NM_021274

NP_001556

NP_067249.1
NP_067249

C-X-C motif chemokine 10 (CXCL10) also known as Interferon gamma-induced protein 10 (IP-10) or small-inducible cytokine B10 is an 8.7 kDa protein that in humans is encoded by the CXCL10 gene. C-X-C motif chemokine 10 is a small cytokine belonging to the CXC chemokine family.

The gene for CXCL10 is located on human chromosome 4 in a cluster among several other CXC chemokines.

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Wikipedia