CXCR3

CXCR3
Identifiers
Aliases	CXCR3, CD182, CD183, CKR-L2, CMKAR3, GPR9, IP10-R, Mig-R, MigR, C-X-C motif chemokine receptor 3
External IDs	OMIM: 300574 MGI: 1277207 HomoloGene: 1153 GeneCards: CXCR3
Gene ontology Molecular function • C-X-C chemokine receptor activity • G-protein coupled receptor activity • C-X-C chemokine binding • signal transducer activity • chemokine binding • receptor activity • chemokine receptor activity Cellular component • cytoplasm • integral component of membrane • membrane • integral component of plasma membrane • cell surface • external side of plasma membrane • plasma membrane Biological process • negative regulation of execution phase of apoptosis • G-protein coupled receptor signaling pathway • movement of cell or subcellular component • positive regulation of execution phase of apoptosis • positive regulation of cAMP metabolic process • positive regulation of cytosolic calcium ion concentration • T cell chemotaxis • chemokine-mediated signaling pathway • positive regulation of release of sequestered calcium ion into cytosol • positive regulation of cAMP-mediated signaling • regulation of leukocyte migration • positive regulation of angiogenesis • negative regulation of endothelial cell proliferation • cell surface receptor signaling pathway • cell adhesion • positive regulation of chemotaxis • angiogenesis • positive regulation of cell proliferation • chemokine (C-C motif) ligand 11 production • negative regulation of angiogenesis • inflammatory response • calcium-mediated signaling • positive regulation of transcription from RNA polymerase II promoter • signal transduction • apoptotic process • chemotaxis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2833	12766
Ensembl	ENSG00000186810	ENSMUSG00000050232
UniProt	P49682	O88410
RefSeq (mRNA)	NM_001142797 NM_001504	NM_009910
RefSeq (protein)	NP_001136269 NP_001495	NP_034040.1 NP_034040
Location (UCSC)	Chr X: 71.62 – 71.62 Mb	Chr X: 101.73 – 101.73 Mb
PubMed search

2833

12766

ENSG00000186810

ENSMUSG00000050232

P49682

O88410

NM_001142797
NM_001504

NM_009910

NP_001136269
NP_001495

NP_034040.1
NP_034040

Chemokine receptor CXCR3 is a Gα_i protein-coupled receptor in the CXC chemokine receptor family. Other names for CXCR3 are G protein-coupled receptor 9 (GPR9) and CD183. There are three isoforms of CXCR3 in humans: CXCR3-A, CXCR3-B and chemokine receptor 3-alternative (CXCR3-alt).CXCR3-A binds to the CXC chemokines CXCL9 (MIG), CXCL10 (IP-10), and CXCL11 (I-TAC) whereas CXCR3-B can also bind to CXCL4 in addition to CXCL9, CXCL10, and CXCL11.

CXCR3 is expressed primarily on activated T lymphocytes and NK cells, and some epithelial cells. CXCR3 and CCR5 are preferentially expressed on Th1 cells, whereas Th2 cells favor the expression of CCR3 and CCR4. CXCR3 ligands that attract Th1 cells can concomitantly block the migration of Th2 cells in response to CCR3 ligands, thus enhancing the polarization of effector T cell recruitment.

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Wikipedia