CCR4

Identifiers

CCR4, CC-CKR-4, CD194, CKR4, CMKBR4, ChemR13, HGCN:14099, K5-5, C-C motif chemokine receptor 4

External IDs

MGI: 107824 HomoloGene: 21135 GeneCards: CCR4

Gene ontology
Molecular function	• C-C chemokine receptor activity • G-protein coupled receptor activity • chemokine receptor activity • signal transducer activity
Cellular component	• integral component of membrane • plasma membrane • integral component of plasma membrane • external side of plasma membrane • membrane • neuronal cell body
Biological process	• positive regulation of cytosolic calcium ion concentration • chemotaxis • chemokine-mediated signaling pathway • G-protein coupled receptor signaling pathway • inflammatory response • neuron migration • homeostasis of number of cells • immune response • signal transduction • tolerance induction • response to bacterium • response to antibiotic • response to radiation • positive regulation of positive chemotaxis
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


1233


12773

Ensembl


ENSG00000183813


ENSMUSG00000047898

UniProt


P51679


P51680

RefSeq (mRNA)


NM_005508


NM_009916

RefSeq (protein)


NP_005499


NP_034046

Location (UCSC)

Chr 3: 32.95 – 32.96 Mb

Chr 9: 114.49 – 114.5 Mb

PubMed search

C-C chemokine receptor type 4 is a protein that in humans is encoded by the CCR4 gene. CCR4 has also recently been designated CD194 (cluster of differentiation 194).

The protein encoded by this gene belongs to the G protein-coupled receptor family. It is a receptor for the following CC chemokines:

Chemokines are a group of small structurally related proteins that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.

...
Wikipedia