CCR5

CCR5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2L87, 2RLL, 2RRS, 2MZX, 4MBS
Identifiers
Aliases	CCR5, CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22, C-C motif chemokine receptor 5 (gene/pseudogene)
External IDs	OMIM: 601373 MGI: 107182 HomoloGene: 37325 GeneCards: CCR5
Targeted by Drug
aplaviroc, cenicriviroc, maraviroc, vicriviroc
Gene ontology Molecular function • C-C chemokine binding • G-protein coupled receptor activity • coreceptor activity • chemokine (C-C motif) ligand 5 binding • virus receptor activity • signal transducer activity • protein binding • chemokine receptor activity • C-C chemokine receptor activity • actin binding • phosphatidylinositol phospholipase C activity Cellular component • cytoplasm • integral component of membrane • endosome • membrane • plasma membrane • integral component of plasma membrane • cell surface • external side of plasma membrane Biological process • G-protein coupled receptor signaling pathway • signaling • response to cholesterol • release of sequestered calcium ion into cytosol by sarcoplasmic reticulum • positive regulation of cytosolic calcium ion concentration • cell-cell signaling • dendritic cell chemotaxis • MAPK cascade • chemotaxis • cellular defense response • cell surface receptor signaling pathway • immune response • inflammatory response • cellular response to lipopolysaccharide • calcium ion transport • calcium-mediated signaling • entry into host cell • signal transduction • fusion of virus membrane with host plasma membrane • chemokine-mediated signaling pathway • viral process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1234	12774
Ensembl	ENSG00000160791	ENSMUSG00000079227
UniProt	P51681	P51682
RefSeq (mRNA)	NM_001100168 NM_000579	NM_009917
RefSeq (protein)	NP_000570.1 NP_001093638.1	NP_034047.2
Location (UCSC)	Chr 3: 46.37 – 46.38 Mb	Chr 9: 124.12 – 124.15 Mb
PubMed search

2L87, 2RLL, 2RRS, 2MZX, 4MBS

1234

12774

ENSG00000160791

ENSMUSG00000079227

P51681

P51682

NM_001100168
NM_000579

NM_009917

NP_000570.1
NP_001093638.1

NP_034047.2

C-C chemokine receptor type 5, also known as CCR5 or CD195, is a protein on the surface of white blood cells that is involved in the immune system as it acts as a receptor for chemokines. This is the process by which T cells are attracted to specific tissue and organ targets. Many forms of HIV, the virus that causes AIDS, initially use CCR5 to enter and infect host cells. Certain individuals carry a mutation known as CCR5-Δ32 in the CCR5 gene, protecting them against these strains of HIV.

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Wikipedia