CCR3 (gene)

CCR3
Identifiers
Aliases	CCR3, CC-CKR-3, CD193, CKR3, CMKBR3, C-C motif chemokine receptor 3
External IDs	MGI: 104616 HomoloGene: 20436 GeneCards: CCR3
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity • protein binding • C-C chemokine receptor activity • chemokine receptor activity Cellular component • integral component of membrane • membrane • integral component of plasma membrane • plasma membrane Biological process • G-protein coupled receptor signaling pathway • positive regulation of endothelial cell proliferation • adenylate cyclase-modulating G-protein coupled receptor signaling pathway • positive regulation of cytosolic calcium ion concentration • chemokine-mediated signaling pathway • positive regulation of angiogenesis • chemotaxis • cellular defense response • cell adhesion • inflammatory response • viral process • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1232	12771
Ensembl	ENSG00000183625	ENSMUSG00000035448
UniProt	P51677	P51678
RefSeq (mRNA)	NM_001164680 NM_001837 NM_178328 NM_178329	NM_009914
RefSeq (protein)	NP_001158152 NP_001828 NP_847898 NP_847899	NP_034044.3 NP_034044
Location (UCSC)	Chr 3: 46.16 – 46.27 Mb	Chr 9: 124.02 – 124.03 Mb
PubMed search

1232

12771

ENSG00000183625

ENSMUSG00000035448

P51677

P51678

NM_001164680
NM_001837
NM_178328
NM_178329

NM_009914

NP_001158152
NP_001828
NP_847898
NP_847899

NP_034044.3
NP_034044

C-C chemokine receptor type 3 is a protein that in humans is encoded by the CCR3 gene.

CCR3 has also recently been designated CD193 (cluster of differentiation 193).

The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway, and possibly at sites of parasitic infection. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants encoding the same protein have been described.

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Wikipedia