CCL11

CCL11
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1EOT, 2EOT, 2MPM
Identifiers
Aliases	CCL11, SCYA11, C-C motif chemokine ligand 11
External IDs	OMIM: 601156 MGI: 103576 HomoloGene: 7929 GeneCards: CCL11
Gene location (Human) Chr. Chromosome 17 (human) Band 17q12 Start 34,285,668 bp End 34,288,334 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 C|11 49.84 cM Start 82,057,823 bp End 82,062,955 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • cytokine activity • protein binding • chemokine activity • CCR3 chemokine receptor binding • protein dimerization activity • receptor ligand activity Cellular component • intracellular • extracellular region • cell • extracellular space Biological process • G-protein coupled receptor signaling pathway • positive regulation of endothelial cell proliferation • positive regulation of actin filament polymerization • response to interleukin-4 • branching involved in mammary gland duct morphogenesis • monocyte chemotaxis • actin filament organization • positive regulation of cell migration • chemokine-mediated signaling pathway • ERK1 and ERK2 cascade • response to interleukin-13 • cellular response to tumor necrosis factor • response to virus • cellular calcium ion homeostasis • mast cell chemotaxis • neutrophil chemotaxis • positive regulation of angiogenesis • mammary duct terminal end bud growth • chemotaxis • protein phosphorylation • positive regulation of GTPase activity • cell adhesion • cytoskeleton organization • cellular response to interleukin-1 • immune response • positive regulation of ERK1 and ERK2 cascade • regulation of cell shape • cellular response to interferon-gamma • lymphocyte chemotaxis • response to radiation • inflammatory response • chronic inflammatory response • signal transduction • eosinophil chemotaxis • antimicrobial humoral immune response mediated by antimicrobial peptide • regulation of receptor activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6356	20292
Ensembl	ENSG00000172156	ENSMUSG00000020676
UniProt	P51671	P48298
RefSeq (mRNA)	NM_002986	NM_011330
RefSeq (protein)	NP_002977	NP_035460
Location (UCSC)	Chr 17: 34.29 – 34.29 Mb	Chr 17: 82.06 – 82.06 Mb
PubMed search

1EOT, 2EOT, 2MPM

6356

20292

ENSG00000172156

ENSMUSG00000020676

P51671

P48298

NM_002986

NM_011330

NP_002977

NP_035460

C-C motif chemokine 11 also known as eosinophil chemotactic protein and eotaxin-1 is a protein that in humans is encoded by the CCL11 gene. This gene is encoded on three exons and is located on chromosome 17.

CCL11 is a small cytokine belonging to the CC chemokine family. CCL11 selectively recruits eosinophils by inducing their chemotaxis, and therefore, is implicated in allergic responses. The effects of CCL11 are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine receptors for which CCL11 is a ligand include CCR2,CCR3 and CCR5. However, it has been found that eotaxin-1 (CCL11) has high degree selectivity for its receptor, such that they are inactive on neutrophils and monocytes, which do not express CCR3.

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