CCL5

CCL5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1B3A, 1EQT, 1HRJ, 1RTN, 1RTO, 1U4L, 1U4M, 1U4P, 1U4R, 2L9H, 2VXW, 5CMD, 5DNF, 5COY
Identifiers
Aliases	CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP, C-C motif chemokine ligand 5
External IDs	OMIM: 187011 MGI: 98262 HomoloGene: 2244 GeneCards: CCL5
Gene ontology Molecular function • CCR5 chemokine receptor binding • receptor signaling protein tyrosine kinase activator activity • chemokine activity • protein self-association • CCR4 chemokine receptor binding • phosphatidylinositol phospholipase C activity • protein kinase activity • cytokine activity • CCR1 chemokine receptor binding • phospholipase activator activity • chemokine receptor binding • protein homodimerization activity • chemokine receptor antagonist activity • protein binding • chemoattractant activity Cellular component • cytoplasm • extracellular region • extracellular space Biological process • leukocyte cell-cell adhesion • positive regulation of cell-cell adhesion mediated by integrin • regulation of T cell activation • positive regulation of smooth muscle cell migration • activation of phospholipase D activity • negative regulation of viral genome replication • positive regulation of ERK1 and ERK2 cascade • positive regulation of innate immune response • cellular response to interferon-gamma • positive regulation of macrophage chemotaxis • calcium ion transport • exocytosis • positive regulation of calcium ion transport • response to cytokine • regulation of insulin secretion • chemokine-mediated signaling pathway • positive regulation of cellular biosynthetic process • response to virus • positive regulation of monocyte chemotaxis • cellular response to fibroblast growth factor stimulus • neutrophil chemotaxis • response to tumor necrosis factor • negative regulation of T cell apoptotic process • positive regulation of GTPase activity • negative regulation of macrophage apoptotic process • positive regulation of T cell proliferation • positive regulation of phosphorylation • inflammatory response • positive regulation of translational initiation • response to toxic substance • G-protein coupled receptor signaling pathway • positive regulation of epithelial cell proliferation • positive regulation of tyrosine phosphorylation of STAT protein • cellular response to organic cyclic compound • cellular calcium ion homeostasis • protein tetramerization • negative regulation by host of viral transcription • chemotaxis • positive regulation of homotypic cell-cell adhesion • cellular response to interleukin-1 • immune response • positive regulation of viral genome replication • positive regulation of JAK-STAT cascade • lipopolysaccharide-mediated signaling pathway • positive regulation of T cell migration • regulation of chronic inflammatory response • positive regulation of smooth muscle cell proliferation • neutrophil activation • protein kinase B signaling • positive regulation of cell migration • positive regulation of natural killer cell chemotaxis • cell-cell signaling • eosinophil chemotaxis • cellular protein complex assembly • dendritic cell chemotaxis • MAPK cascade • macrophage chemotaxis • positive regulation of T cell chemotaxis • regulation of neuron death • positive regulation of phosphatidylinositol 3-kinase signaling • negative regulation of G-protein coupled receptor protein signaling pathway • positive regulation of T cell apoptotic process • positive regulation of cell adhesion • negative regulation of chemokine-mediated signaling pathway • monocyte chemotaxis • positive chemotaxis • positive regulation of protein tyrosine kinase activity • cellular response to tumor necrosis factor • positive regulation of activation of Janus kinase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6352	20304
Ensembl	n/a	ENSMUSG00000035042
UniProt	P13501	P30882
RefSeq (mRNA)	NM_002985 NM_001278736	NM_013653
RefSeq (protein)	NP_001265665 NP_002976	NP_038681.2 NP_038681
Location (UCSC)	Chr 17: 35.87 – 35.88 Mb	Chr 11: 83.53 – 83.53 Mb
PubMed search

1B3A, 1EQT, 1HRJ, 1RTN, 1RTO, 1U4L, 1U4M, 1U4P, 1U4R, 2L9H, 2VXW, 5CMD, 5DNF, 5COY

6352

20304

n/a

ENSMUSG00000035042

P13501

P30882

NM_002985
NM_001278736

NM_013653

NP_001265665
NP_002976

...
Wikipedia