CCL7

CCL7
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1BO0, 1NCV, 4ZKC
Identifiers
Aliases	CCL7, FIC, MARC, MCP-3, MCP3, NC28, SCYA6, SCYA7, C-C motif chemokine ligand 7
External IDs	OMIM: 158106 HomoloGene: 4568 GeneCards: CCL7
Gene ontology Molecular function • cytokine activity • heparin binding • chemokine activity • CCR1 chemokine receptor binding • protein binding • CCR2 chemokine receptor binding Cellular component • cell • extracellular region • extracellular space Biological process • G-protein coupled receptor signaling pathway • monocyte chemotaxis • positive regulation of cell migration • positive regulation of natural killer cell chemotaxis • chemokine-mediated signaling pathway • cellular response to tumor necrosis factor • cell-cell signaling • eosinophil chemotaxis • cellular calcium ion homeostasis • neutrophil chemotaxis • chemotaxis • positive regulation of GTPase activity • cytoskeleton organization • cellular response to interleukin-1 • immune response • positive regulation of ERK1 and ERK2 cascade • regulation of cell shape • cellular response to interferon-gamma • inflammatory response • signal transduction • response to gamma radiation • cellular response to ethanol Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6354	n/a
Ensembl	ENSG00000108688	n/a
UniProt	P80098	n/a
RefSeq (mRNA)	NM_006273	n/a
RefSeq (protein)	NP_006264	n/a
Location (UCSC)	Chr 17: 34.27 – 34.27 Mb	n/a
PubMed search		n/a

1BO0, 1NCV, 4ZKC

6354

n/a

ENSG00000108688

n/a

P80098

n/a

NM_006273

n/a

NP_006264

n/a

Chemokine (C-C motif) ligand 7 (CCL7) is a small cytokine known as a chemokine that was previously called monocyte-chemotactic protein 3 (MCP3). Due to CCL7 possessing two adjacent N-terminal cysteine residues in its mature protein, it is classified among the subfamily of chemokines known as CC chemokines. CCL7 specifically attracts monocytes, and regulates macrophage function. It is produced by certain tumor cell lines and by macrophages. This chemokine is located on chromosome 17 in humans, in a large cluster containing many other CC chemokines and is most closely related to CCL2 (previously called MCP1).

CCL7 has been shown to interact with MMP2. It bind to the CCR2 receptor.

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Wikipedia