U.S. Route 52 in South Carolina
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| Route information | ||||
| Maintained by SCDOT | ||||
| Length: | 159.7 mi (257.0 km) | |||
| Existed: | 1935 – present | |||
| Major junctions | ||||
| South end: | Line Street in Charleston | |||
  I-26 / US 17 in Charleston US 78 in Charleston I-526 in North Charleston US 17 Alt. in Moncks Corner US 521 near Greeleyville US 378 in Lake City  US 301 / SC 341 in Effingham US 76 in Florence I-95 in Florence  US 1 / SC 9 in Cheraw
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| North end: |
 US 52 at the NC line, near Cheraw
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| Location | ||||
| Counties: | Charleston, Berkeley, Williamsburg, Florence, Darlington, Chesterfield | |||
| Highway system | ||||
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U.S. Route 52 (US 52) is a North–South U.S. Highway that runs 161 miles (259 km) from Charleston to the North Carolina state line near Cheraw. It serves as a strategic highway through the central South Carolina. Though an even-numbered U.S. Route, it is signed north-south in South Carolina (standard convention being to label even-numbered U.S. Routes with east-west designations). In some other states along its route, it is signed east-west. The South Carolina segment is signed such that U.S. 52 north corresponds to the general westward direction of the highway, and vice versa.
US 52 begins at the intersection of Meeting and Line Streets, in Charleston. Going northwest along Meeting Street, it connects with I-26/US 17, followed by Morrison Drive (US 52 Spur hidden); US 52 signage begin to appear north of Morrison Drive. In North Charleston, it shares a concurrency with US 78 for 11 miles (18 km), splitting near Goose Creek. In Moncks Corner it connects with US 17 Alt briefly as it enters and traverses through Francis Marion National Forest. Continuing north, it goes through St. Stephen, Kingstree and Lake City, before joining another short concurrency with US 301 from Effingham to Florence. Through downtown Florence, it goes northwest and bypasses Darlington and joining another concurrency with US 401. At Society Hill, it merges briefly with US 15 before continuing north again solo to Cheraw, where it overlaps briefly with US 1 and SC 9. US 52 crosses the North Carolina state line, after traveling 159.7 miles (257.0 km) through South Carolina, continuing on towards Wadesboro.
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