List of U.S. Highways in South Carolina

U.S. Highways of South Carolina
Highway marker for U.S. Highways in South Carolina
System information
Maintained by SCDOT
Formed:	November 11, 1926 (1926-11-11)
Highway names
US Highways:	U.S. Highway nn (US nn)
System links
South Carolina State Highway System Interstate U.S. State Scenic

There are 23 U.S. Highways that exist entirely or partially in the U.S. state of South Carolina. In South Carolina, all U.S. Highways are maintained by the South Carolina Department of Transportation (SCDOT).