U.S. Route 15 in South Carolina
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| Route information | ||||
| Maintained by SCDOT | ||||
| Length: | 158.58 mi (255.21 km) | |||
| Existed: | 1935 – present | |||
| Major junctions | ||||
| South end: |
  US 17 Alt. in Walterboro
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 US 78 in St. George  US 178 / I-26 in Rosinville US 176 near Holly Hill  I-95 / US 301 from Santee to Summerton   US 76 / US 378 / US 521 in Sumter I-20 in Bishopville  US 401 / US 52 in Society Hill SC 9 in Bennettsville
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| North end: |
 US 15 in McColl
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| Location | ||||
| Counties: | Marlboro, Darlington, Lee, Sumter, Clarendon, Orangeburg, Colleton | |||
| Highway system | ||||
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In the U.S. state of South Carolina, U.S. Route 15 (US 15) is a north–south highway, it runs from McColl to Walterboro.
Starting at ALT US 17 in Walterboro US 15 goes east. It runs parallel to I-95 and across I-26. Then it turns north and crosses I-95. Just before the town of Santee US 15 converges with US 301. In Santee the two highways merge with I-95 at exit 98 and all three cross Lake Marion. At exit 102, US 15/301 split off from I-95 and go into the town of Summerton. US 15 then separates from US 301 and heads mainly north to city of Sumter. From there it continues north, crosses I-20, goes through the cities of Bishopville and Hartsville to the town of Society Hill. It is here that US 401 joins US 15 and both go to the North Carolina border.
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