U.S. Route 76 in South Carolina
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| Route information | ||||
| Maintained by SCDOT | ||||
| Length: | 297.9 mi (479.4 km) | |||
| Existed: | 1926 – present | |||
| Major junctions | ||||
| West end: |
  US 76 / SR 2 at the Georgia state line near Clayton
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 I-85 near Anderson  I-26 / US 176 in Irmo I-20 on the Seven Oaks–St. Andrews city line I-26 / I-126 near West Columbia  US 1 / US 378 in Columbia   US 15 / US 401 / US 378 / US 521 in Sumter I-95 near Florence
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| East end: |
US 76 at the North Carolina state line near Fair Bluff, NC
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| Location | ||||
| Counties: | Oconee, Pickens, Anderson, Greenville, Laurens, Newberry, Lexington, Richland, Sumter, Florence, Marion, Horry | |||
| Highway system | ||||
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| Location: | Seneca, South Carolina |
| Existed: | 1958–2000 |
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| Location: | Laurens, South Carolina |
| Length: | 3.8 mi (6.1 km) |
| Existed: | 1982–present |
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| Location: | Newberry, South Carolina |
| Existed: | 1952–2001 |
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| Location: | Columbia, South Carolina |
| Length: | 4.4 mi (7.1 km) |
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| Location: | Sumter, South Carolina |
| Length: | 5.9 mi (9.5 km) |
| Existed: | 1959–present |
U.S. Route 76 (US 76) is an east–west U.S. highway in the U.S. state of South Carolina. Being one of the longest highways in the state, it connects the cities of Anderson, Columbia, Sumter and Florence.
US 76 enters South Carolina across the Chattooga River, then continues southeast toward Westminster. This segment is a moderately windy two-lane road. In Westminster, it heads east toward Seneca and Clemson. From Clemson, the road heads southeast toward Anderson, intersecting Interstate 85 (I-85), then east toward the small towns of Belton and Honea Path. US 76 is a four-lane highway from Westminster to Anderson. In Anderson, the road widens to six lanes with a reversible turn lane. After a concurrency with US 178, the road narrows to five lanes, and, as it goes south towards downtown Anderson, it narrows againk to four. However, the sections around Seneca, Clemson, and Anderson are well developed with many traffic lights. It travels concurrent with US 123 from Westminster to Clemson, SC 28 from Seneca to Anderson, and US 178 from Anderson to Honea Path.
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