Florence /ˈflɔːrəns/ is a city in Florence County, South Carolina, United States. It is the county seat of Florence County and the primary city within the Florence metropolitan area. The area forms the core of the historical "Pee Dee" region of South Carolina, which includes the eight counties of northeastern South Carolina, along with sections of southeastern North Carolina. As of the 2010 census, the population of Florence was 37,056, and the estimated population in 2015 was 38,228.

In 1965, Florence was named an All-American City, presented by the National Civic League. The city was founded as a railroad hub and became the junction of three major railroad systems, including the Wilmington and Manchester, the Northeastern, and the Cheraw and Darlington. As of 2013^[update], the city retains its status as a major hub, both for industry and infrastructure, while establishing itself as a regional center for business, medicine, culture and finance.

The City of Florence was chartered in 1871 and incorporated in 1890 following the 1888 creation of Florence County. Prior to its charter, the city was part of one of the original townships laid out by the Lords Proprietors in 1719. The area was gradually settled through the late 19th and early 20th century. Early settlers practiced subsistence farming and produced indigo, cotton, naval stores and timber, which were shipped down the Pee Dee River to the port at Georgetown and exported. In the mid-19th century two intersecting railroads were built, the Wilmington and Manchester, and the Northeastern. Gen. W. W. Harllee, the president of the W & M, built his home at the junction, and named the community "Florence", after his daughter.

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