U.S. Route 78 in South Carolina
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| Route information | ||||
| Maintained by SCDOT | ||||
| Length: | 141.0 mi (226.9 km) | |||
| Existed: | 1927 – present | |||
| Major junctions | ||||
| West end: |
      US 1 / US 25 / US 78 / US 278 / SR 10 / SR 121 at the GA line near North Augusta
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 I-520 / US 25 in North AugustaUS 278 in ClearwaterUS 1 in Aiken US 321 in Denmark  US 301 / US 601 in Bamberg US 21 in Branchville  I-95 / US 15 in St. George I-26 near Ladson  I-26 / I-526 / US 52 in North Charleston
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| East end: | Line Street in Charleston | |||
| Location | ||||
| Counties: | Aiken, Barnwell, Bamberg, Orangeburg, Dorchester, Charleston | |||
| Highway system | ||||
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U.S. Route 78 (US 78) is a U.S. highway that travels from Memphis, Tennessee to Charleston, South Carolina. In the U.S. state of South Carolina, it runs from the Savannah River at North Augusta to its eastern terminus in Charleston; connecting the cities of Aiken, Summerville, and North Charleston.
US 78 enters South Carolina by crossing the Savannah River in North Augusta; sharing concurrences with US 1, US 25, US 278 and SC 121. In the immediate 2-mile (3.2 km) area, it sheds most concurrences, sharing only with US 1 towards Aiken; it also connects with I-520, which is a partial beltway around the Augusta metropolitan area. In Aiken, it travels through the downtown area, where US 1 splits north towards Columbia. West of Williston is SC 781, which connects back with US 278; the routing allows travelers to bypass Aiken all together between Williston and Augusta.
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