U.S. Route 278 in South Carolina
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| Route information | ||||
| Auxiliary route of US 78 | ||||
| Maintained by SCDOT | ||||
| Length: | 146.0 mi (235.0 km) | |||
| Existed: | 1965 – present | |||
| Major junctions | ||||
| West end: |
      US 1 / US 25 / US 78 / US 278 / SR 10 / SR 121 at the GA state line near North Augusta
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 I-520 in North Augusta US 301 in Allendale US 321 in Fairfax US 601 in Hampton US 17 in Ridgeland I-95 in Hardeeville
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| East end: |
   US 278 Bus. in Hilton Head
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| Location | ||||
| Counties: | Aiken, Barnwell, Allendale, Hampton, Jasper, Beaufort | |||
| Highway system | ||||
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U.S. Route 278 (US 278) is an east–west United States highway that traverses through the South Carolina Lowcountry, from North Augusta to Hilton Head Island.
After crossing the Savannah River from Georgia, US 278 bypasses downtown North Augusta, South Carolina to the south en route to Beech Island and Johnson Crossroads. It then forms a de facto northern boundary of the Savannah River Site, crossing into the property on a few occasions. The route then continues eastward and then southward through the communities of Barnwell, Kline, Allendale, Fairfax, Hampton, Varnville, Ridgeland, and Hardeeville where it meets I-95. US 278 shares the route between Ridgeland and Hardeeville with US 17.
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