U.S. Route 301 in South Carolina
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| Route information | ||||
| Auxiliary route of US 1 | ||||
| Maintained by SCDOT | ||||
| Length: | 190.3 mi (306.3 km) | |||
| Existed: | 1970 – present | |||
| Major junctions | ||||
| South end: |
  US 301 / SR 73 at the GA state line near Allendale
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 US 278 in Allendale US 321 in Ulmer  US 21 / US 601 in Orangeburg I-26 near Orangeburg US 176 near Elloree  US 15 / I-95 near Summerton US 521 in Manning US 378 in Turbeville US 52 in Effingham  US 76 / SC 327 near Mars Bluff
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| North end: |
 US 301 / US 501 / I‑95 at the NC state line near Hamer
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| Location | ||||
| Counties: | Allendale, Bamberg, Orangeburg, Clarendon, Florence, Marion, Dillon | |||
| Highway system | ||||
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| Location: | Pee Dee, SC-NC state line |
| Length: | 24.4 mi (39.3 km) |
| Existed: | 1927–1932 |
U.S. Route 301 (US 301) runs north–south from the Savannah River southwest of Allendale to Hamer approaching the South of the Border roadside attraction complex.
US 301 enters South Carolina over the Savannah River southwest of Allendale. Concurrencies include US 321 in and around Ulmer, US 601 between Bamberg and Orangeburg, then I-95/US 15 Santee, at Exit 97 before all three move across Lake Marion. The US 15-301 multiplex leaves I-95 at Exit 102, running in close proximity to I-95, but US 15 breaks away at Summerton. Other concurrencies include US 521 in Manning, US 52 between Effingham and just south of Florence, US 76 eastbound from east of Florence until Pee Dee, and finally joins US 501 in Latta, where they both approach the South of the Border roadside attraction complex at the interchange with I-95 on the north–South Carolina border.
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