U.S. Route 25 in South Carolina
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| Route information | ||||
| Maintained by SCDOT | ||||
| Length: | 140.6 mi (226.3 km) | |||
| Existed: | 1927 – present | |||
| Major junctions | ||||
| South end: |
      US 1 / US 25 / US 78 / US 278 / SR 10 / SR 121 at the GA state line near North Augusta
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 I-20 in North Augusta US 378 near Limestone  US 178 / US 221 in Greenwood US 76 in Princeton I-185 near Canterbury I-85 near Greenville I-185 / US 29 near Greenville US 123 near Greenville US 276 in Travelers Rest
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| North end: |
US 25 at the NC line near Travelers Rest
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| Location | ||||
| Counties: | Aiken, Edgefield, McCormick, Greenwood, Laurens, Greenville | |||
| Highway system | ||||
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U.S. Route 25 (US 25) is a U.S. Highway that travels from Brunswick, Georgia to the Kentucky-Ohio state line, where Covington, Kentucky meets Cincinnati, Ohio at the Ohio River. In the U.S. state of South Carolina, it begins as a 140.4-mile-long (226.0 km) highway that travels south to north in the western part of the state, serving the northern part of the Augusta metropolitan area, Greenwood, and Greenville on its path from North Augusta to North Carolina in the Saluda Mountains, near Travelers Rest.
US 25, from I-85 to the North Carolina state line, is part of the Appalachian Development Highway System (ADHS), which is part of Appalachian Regional Commission (ARC). Of the 30.7-mile (49.4 km) section of US 25, only 22.9-mile (36.9 km) was authorized for ADHS funding. In the 2013 fiscal year, South Carolina completed Corridor W and also became the first state to complete its entire ADHS miles among all 13 Appalachian states. The entire section of US 25 along Corridor W boasts a four-to-six-lane limited-access road, with interchanges at major intersections.
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