U.S. Route 17 Alternate (South Carolina)
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| Route information | |
| Alternate route of US 17 | |
| Maintained by SCDOT | |
| Length: | 123.4 mi (198.6 km) |
| Existed: | 1951 – present |
| Major junctions | |
| South end: |
  US 17 / US 21 near Pocotaligo
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 US 15 in Walterboro US 78 in Summerville I-26 in Summerville US 176 in Summerville US 52 in Moncks Corner US 521 in Sampit
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| North end: |
 US 17 / US 701 in Georgetown
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| Highway system | |
U.S. Route 17 Alternate (US 17 Alt) is an alternate route of U.S. Route 17 in South Carolina that runs between Pocotaligo and Georgetown. It is 123.4 miles (198.6 km) long and has been four-laned in various segments since 1970.
US 17 Alt starts at the northern terminus of the US 17-21 overlap near Pocotaligo as a two-lane highway. It heads north along US 21 through Yemassee, where it passes over the CSX Charleston Subdivision and then an over SC 68. Due to the presence of a parallel railroad spur along the north side of SC 68, access to and from US ALT 17-21 is only available from bi-directional on-off ramps on the southwest and southeast corners of the bridge. The multiplex continues until US 21 branches off on its own to the northwest. From here it runs through Hendersonville, and then Walterboro, where it merges with SC 63, becomes the northern terminus of SC 303, and the southern terminus of US 15. From that point, US 17 Alt moves away from I-95, running along the southeast side of Lowcountry Regional Airport and moving further northeast. In Summerville, it intersects US 78, has an interchange with I-26, and intersects US 176. At Moncks Corner, it intersects US 52 and crosses the Dennis Bishop Bridge over the Cooper River. Aftet crossing the W.H. Andrews Memorial Bridge over the Santee River, it joins another multiplex with US 521 in Sampit, and both routes finally terminate at US 17, along with the southern terminus of US 701 in Georgetown.
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