5-HT1D receptor

HTR1D
Identifiers
Aliases	HTR1D, 5-HT1D, HT1DA, HTR1DA, HTRL, RDC4, 5-HT1D receptor, 5-hydroxytryptamine receptor 1D
External IDs	MGI: 96276 HomoloGene: 20240 GeneCards: HTR1D
Targeted by Drug
ergotamine, frovatriptan, 1-naphthylpiperazine, 2-methyl-5-HT, 5-carboxamidotryptamine, pathogen, 5-methoxytryptamine, (+/-)-8-hydroxy-2-(di-N-propylamino)tetralin, alniditan, α-methyl-5-HT, aripiprazole, cgs 12066b-parent, clozapine, CP-122288, dihydroergotamine, dimethyltryptamine, donitriptan, eletriptan, EMDT, lysergic acid, lysergol, naratriptan, olanzapine, quetiapine, rizatriptan, ru-24969, sumatriptan, 1-(3-trifluoromethylphenyl)piperazine, tryptamine, xanomeline, ziprasidone, zolmitriptan, brl-15572, bromocriptine, cabergoline, gr-127935, lisuride, oxymetazoline, pergolide, roxindole, sb-216641, terguride, bufotenine, cyanopindolol, fluspirilene, haloperidol, m-chlorophenylpiperazine, ketanserin, metergoline, methysergide, ocaperidone, pipamperone, α-yohimbine, risperidone, ritanserin, SB-277,011-A, sertindole, spiperone, yohimbine, zotepine, metitepine
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity • G-protein coupled serotonin receptor activity • neurotransmitter receptor activity • serotonin binding Cellular component • integral component of membrane • plasma membrane • integral component of plasma membrane • membrane Biological process • intestine smooth muscle contraction • regulation of locomotion • smooth muscle contraction • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • G-protein coupled receptor signaling pathway • regulation of behavior • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway • response to toxic substance • vasoconstriction • signal transduction • chemical synaptic transmission • G-protein coupled serotonin receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3352	15552
Ensembl	ENSG00000179546	ENSMUSG00000070687
UniProt	P28221	Q61224
RefSeq (mRNA)	NM_000864	NM_001285482 NM_001285483 NM_001285484 NM_008309
RefSeq (protein)	NP_000855	NP_001272411.1 NP_001272412.1 NP_001272413.1 NP_032335.2 NP_001272411 NP_001272412 NP_001272413 NP_032335
Location (UCSC)	Chr 1: 23.19 – 23.19 Mb	Chr 4: 136.42 – 136.44 Mb
PubMed search

3352

15552

ENSG00000179546

ENSMUSG00000070687

P28221

Q61224

NM_000864

NM_001285482
NM_001285483
NM_001285484
NM_008309

NP_000855

NP_001272412
NP_001272413
NP_032335

5-hydroxytryptamine (serotonin) receptor 1D, also known as HTR1D, is a 5-HT receptor, but also denotes the human gene encoding it. 5-HT_1D acts on the central nervous system, and affects locomotion and anxiety. It also induces vascular vasoconstriction in the brain.

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Wikipedia