N,N-Dimethyltryptamine
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Oral (with an MAOI), insufflated, rectal, vaporized, IM, IV |
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| ECHA InfoCard | 100.000.463 |
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| Formula | C12H16N2 |
| Molar mass | 188.269 g/mol |
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| Density | 1.099 g/cm3 |
| Melting point | 40 °C (104 °F) |
| Boiling point | 160 °C (320 °F) @ 0.6 Torr (80 Pa) also reported as 80–135 °C (176–275 °F) @ 0.03 Torr (4.0 Pa) |
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N,N-Dimethyltryptamine (DMT or N,N-DMT) is a powerful psychedelic compound of the tryptamine family. It is a structural analog of serotonin and melatonin and a functional analog of other psychedelic tryptamines such as 4-AcO-DMT, 5-MeO-DMT, 5-HO-DMT, psilocybin (4-PO-DMT), and psilocin (4-HO-DMT).
Historically, it has been consumed by indigenous Amazonian Indian cultures in the form of ayahuasca for divinatory and healing purposes. It was first synthesised in 1931, and in 1946, microbiologist Oswaldo Gonçalves de Lima discovered its natural presence in plants. In the 1960s, it was detected in mammalian organisms as well.
DMT is known for its relatively short duration of action, intense effects and rapid onset. For that reason, DMT was known as a "businessman's trip" during the 1960s in the United States.
DMT can be inhaled, injected, or orally ingested, and its effects depend on the dose, both of DMT and of any MAOI taken with it. The effects last a short period of time, 5 to 15 min. Longer effects can be achieved by oral ingestion: over 3 hours. DMT can produce psychedelic experiences involving euphoria and hallucinations. In most countries, DMT is illegal.
The dependence potential of DMT and the risk of sustained psychological disturbance are minimal when used for religious ceremonies. DMT, like most psychedelics, is considered to be neither addictive, nor toxic, although there is a rare chance some might develop a psychological dependence.
According to a dose-response study, "dimethyltryptamine dose slightly elevated blood pressure, heart rate, pupil diameter, and rectal temperature, in addition to elevating blood concentrations of beta-endorphin, corticotropin, cortisol, and prolactin. Growth hormone blood levels rose equally in response to all doses of DMT, and melatonin levels were unaffected."
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