U.S. Highway 378

U.S. Route 378
Route information
Auxiliary route of US 78
Length	234.30 mi (377.07 km)
Existed	1952 – present
Major junctions
West end	US 78 / SR 10 / SR 17 / SR 47 in Washington, GA
	US 178 in Saluda, SC US 1 in Lexington, SC I-20 near West Columbia, SC I-26 in West Columbia, SC US 21 / US 176 / US 321 in Columbia, SC I-77 in Columbia, SC US 15 in Sumter, SC US 76 in Sumter, SC I-95 near Turbeville, SC US 52 near Lake City, SC
East end	US 501 Bus. in Conway, SC
Location
States	Georgia, South Carolina
Counties	GA: Wilkes, Lincoln SC: McCormick, Edgefield, Saluda, Lexington, Richland, Sumter, Clarendon, Florence, Marion, Horry
Highway system
United States Numbered Highway System List Special Divided Replaced ← SR 377 GA SR 378 → ← SC 377 SC SC 381 →

U.S. Route 378 Business
Location	Sumter, South Carolina
Length	6.6 mi (10.6 km)
Existed	1961–N/A

U.S. Route 378 Business
Location	Lake City, South Carolina
Length	4.49 mi (7.23 km)
Existed	1958–present

U.S. Route 378 (US 378) is a spur of US 78 in the U.S. states of Georgia and South Carolina. The U.S. Highway runs 234.30 miles (377.07 km) from US 78, Georgia State Route 10 (SR 10), SR 17, and SR 47 in Washington, Georgia, east to US 501 Business in Conway, South Carolina. US 378 connects the Central Savannah River Area in both states with the Midlands and Pee Dee regions of South Carolina. The U.S. Highway's western portion, which connects Washington and Lincolnton in Georgia and McCormick, Saluda, and Lexington in South Carolina, is mainly a rural highway. US 378 is a major suburban and urban highway through Lexington and the South Carolina state capital, Columbia. The highway has a lengthy concurrency with US 76 between Columbia and Sumter and serves as a major route between the Midlands and the Myrtle Beach area, between which the highway has a business route through Lake City.

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Wikipedia