Numerous buildings and structures located in Conway are on the National Register of Historic Places. Among these is the City Hall building, designed by Robert Mills, architect of the Washington Monument. Since the completion of the Main Street USA project in the 1980s, Conway's downtown has been revitalized with shops and bistros. Highlighting the renovation of the downtown area is the Riverwalk, an area of fine dining which follows a stretch of the Waccamaw River that winds through Conway.

Conway is one of the oldest towns in South Carolina. Originally early English colonists named the village as named "Kings Town" but soon changed it to "Kingston". The town was founded in 1732 as part of Royal Governor Robert Johnson's Township Scheme. It was laid out on a bluff overlooking the Waccamaw River in what is now known as Horry County.

Many area residents fought in the American Revolution, and small engagements were fought near Kingston at Bear Bluff and at Black Lake. Francis Marion, who was known as the "Swamp Fox", had an encampment near Kingston just across the Waccamaw River.

After the war, patriotic citizens wanted to discard the name that honored Great Britain's King George II. The County's name was changed to Horry (pronounced oh-ree) in honor of General Peter Horry in 1801, and a courthouse was established in Kingston. "Kingston" was later changed to "Conwayborough", for General Robert Conway. In 1883, the General Assembly changed the name to the current name of Conway.

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